{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T13:39:42Z","timestamp":1784727582850,"version":"3.55.0"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,10,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Moyamoya vasculopathy (MMV) is a rare cerebrovascular disease of unclear cause. In this study, we aimed to determine whether metabolic syndrome (MetS) is associated with the development of MMV and subsequent stroke risk in young adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Using a nationwide database, we retrospectively analyzed the data of 6\u2009891\u2009400 Korean adults aged 20 to 40\u2009years who underwent health screening between 2009 and 2012. Participants were monitored until December 31, 2021, to identify patients newly diagnosed with MMV. We further examined the risk of ischemic and hemorrhagic stroke in patients newly diagnosed with MMV without prior stroke. Hazard ratios (HR) were calculated using multivariable Cox regression models adjusted for relevant confounders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Over a median follow\u2010up of 9.65\u2009years, 1754 individuals developed MMV. These participants exhibited significantly poorer baseline metabolic profiles, including a higher body mass index and a higher prevalence of diabetes, hypertension, and dyslipidemia (all\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      \u2009&lt;\u20090.0001). Metabolic syndrome was associated with a significantly increased risk of MMV development (adjusted HR, 2.94 [95% CI, 2.60\u20133.33]). The association between metabolic derangements and MMV risk was stronger in women. Among newly diagnosed patients with MMV, metabolic syndrome was associated with an increased risk of subsequent stroke (adjusted HR, 2.05 [95% CI, 1.25\u20133.37]), primarily ischemic stroke.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Metabolic syndrome could substantially increase the risk of MMV development and subsequent stroke events in young adults. These findings emphasize the importance of managing metabolic health to prevent MMV and related neurological outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.042852","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T03:17:11Z","timestamp":1761103031000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Metabolic Syndrome and Risk of Moyamoya Vasculopathy and Subsequent Stroke in Young Adults"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0533-9786","authenticated-orcid":false,"given":"Joonyub","family":"Lee","sequence":"first","affiliation":[{"name":"The Catholic University of Korea","place":["Seoul, Republic of 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