{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:25:51Z","timestamp":1790385951976,"version":"4.1.0"},"reference-count":58,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"18","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,9,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Kidney dysfunction, defined by measures of glomerular health, in patients hospitalized with acute heart failure (HF) is associated with death and HF readmission. We aimed to determine if kidney tubule damage and dysfunction are associated with these outcomes in acute HF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">In AKINESIS (Acute Kidney Injury Neutrophil Gelatinase\u2010Associated Lipocalin [NGAL] Evaluation of Symptomatic Heart Failure Study), 218 individuals admitted with acute HF experiencing acute kidney injury were matched with 218 individuals without acute kidney injury. Fourteen urine tubular damage and dysfunction biomarkers were measured at hospital admission in this case\u2013control cohort. Associations between biomarkers and the composite outcome of death or HF readmission, death alone, and HF readmission alone were evaluated adjusting for confounders including kidney and cardiac biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      The mean age was 71\u00b112\u2009years, 64% were men, and mean admission estimated glomerular filtration rate was 55\u00b123 mL\/min per 1.73 m\n                      <jats:sup>2<\/jats:sup>\n                      . There were 156 deaths or HF readmissions, 87 deaths, and 92 HF readmissions over 1 year. Each 2\u2010fold higher level of IGFBP\u20107 (insulin\u2010like growth factor binding protein\u20107), IGFBP\u20107*TIMP\u20102 (tissue inhibitor of metalloproteinases\u20102) product, KIM\u20101 (kidney injury molecule\u20101), and MCP\u20101 (monocyte chemoattractant protein\u20101) was associated with a 1.36 (95% CI, 1.13\u20131.64), 1.08 (95% CI, 1.01\u20131.14), 1.12 (95% CI, 1.02\u20131.24), and 1.18 (95% CI, 1.03\u20131.34) higher risk of death or HF readmission, respectively. IGFBP\u20107 was associated with death alone, whereas MCP\u20101 and CCL\u201014 (C\u2010C motif chemokine ligand\u201014) were associated with HF readmission alone.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Biomarkers of kidney tubular health are associated with risk of death and HF readmission among people admitted with acute HF independent of measures of glomerular function and cardiac risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.042880","type":"journal-article","created":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T04:39:28Z","timestamp":1757133568000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Kidney Tubular Biomarkers Predict Risk of Death and Heart Failure Readmission in Acute Heart Failure"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6122-1152","authenticated-orcid":false,"given":"Nicholas","family":"Wettersten","sequence":"first","affiliation":[{"name":"San Diego Veterans Affairs Medical Center","place":["San Diego, USA"]},{"name":"University of California","place":["San Diego, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1270-1181","authenticated-orcid":false,"given":"Stephen","family":"Duff","sequence":"additional","affiliation":[{"name":"University College Dublin","place":["Dublin, Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9053-1099","authenticated-orcid":false,"given":"Yu","family":"Horiuchi","sequence":"additional","affiliation":[{"name":"Mitsui Memorial Hospital","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1611-7935","authenticated-orcid":false,"given":"Dirk J.","family":"van Veldhuisen","sequence":"additional","affiliation":[{"name":"University Medical Center Groningen, University of Groningen","place":["Groningen, the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8902-9576","authenticated-orcid":false,"given":"Michelle M.","family":"Estrella","sequence":"additional","affiliation":[{"name":"Veterans Affairs San Francisco Healthcare System","place":["San Francisco, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9559-204X","authenticated-orcid":false,"given":"Michael G.","family":"Shlipak","sequence":"additional","affiliation":[{"name":"University of California","place":["San Francisco, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Maisel","sequence":"additional","affiliation":[{"name":"University of California","place":["San Diego, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8516-1839","authenticated-orcid":false,"given":"Patrick T.","family":"Murray","sequence":"additional","affiliation":[{"name":"University College Dublin","place":["Dublin, Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8084-9869","authenticated-orcid":false,"given":"Joachim H.","family":"Ix","sequence":"additional","affiliation":[{"name":"University of California San Diego","place":["San Diego, 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