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However, these agents are associated with significant cardiovascular toxicities, including hypertension, thrombosis, and heart failure, which may increase when combined with other cancer treatments, such as chemotherapy or immunotherapy. This meta\u2010analysis aims to evaluate the cardiovascular adverse events linked to\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">AIs<\/jats:styled-content>\n                      , focusing on their types, incidence, and severity of these adverse events to provide a clearer understanding of the cardiovascular risks associated with\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">AIs<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">A systematic review was conducted for randomized controlled trials that assessed AI therapies. The data from 64 studies involving 27\u2009639 patients were analyzed using a random\u2010effects model. Major adverse cardiovascular events such as hypertension, thrombosis, arrhythmias, myocardial ischemia, and left ventricular dysfunction were the primary outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">The analysis revealed that AI treatment significantly increased the incidence of hypertension (relative risk [RR], 3.28 [95% CI, 2.82\u20134.30]), myocardial ischemia or infarction events (RR, 2.09 [95% CI, 1.05\u20134.17]), arrhythmia events (RR, 1.25 [95% CI, 0.90\u20131.74]), thrombotic events (RR, 1.46 [95% CI, 1.11\u20131.92]), and left ventricular dysfunction (RR, 2.00 [95% CI, 1.18\u20133.41]). Subgroup analyses indicated that the combination of AIs with chemotherapy or other targeted therapies heightened these risks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">AIs significantly increase the risk of cardiovascular events in patients with cancer, particularly when combined with other treatments. Clinicians should balance the benefits and cardiovascular risks of AIs and consider strategies to reduce these adverse effects. Further research is needed to refine these insights.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.042896","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:18:20Z","timestamp":1762175900000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Major Adverse Cardiovascular Events in Angiogenesis Inhibitor\u2010Based Cancer Therapy: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5307-7202","authenticated-orcid":false,"given":"Yuxuan","family":"Tao","sequence":"first","affiliation":[{"name":"Guang\u2019anmen Hospital, Chinese Academy of Traditional Chinese Medicine","place":["Beijing, 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