{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T16:13:11Z","timestamp":1785859991682,"version":"3.56.0"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,10,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Phenylacetylglutamine was reported to be associated with ischemic stroke and cognitive performance, but its association with poststroke cognitive impairment (PSCI) remained unclear. We aimed to prospectively investigate the association between plasma phenylacetylglutamine levels and PSCI at 3 months in a multicenter cohort study.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">A total of 617 patients with ischemic stroke were included on the basis of a preplanned ancillary study from CATIS (China Antihypertensive Trial in Acute Ischemic Stroke). PSCI was evaluated using the Mini\u2010Mental State Examination scale and Montreal Cognitive Assessment scale. Logistic regression analyses were performed to evaluate the association between plasma phenylacetylglutamine and the risk of 3\u2010month PSCI.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              According to the Mini\u2010Mental State Examination score, a total of 376 participants developed PSCI at 3 months. After adjustment for age, sex, education, and other important risk factors, the multivariable\u2010adjusted odds ratio of PSCI for the highest tertile of phenylacetylglutamine was 2.16 (95% CI, 1.32\u20133.54;\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              <jats:sub>trend<\/jats:sub>\n              =0.002) compared with the lowest tertile. A multiple\u2010adjusted spline regression model showed a positive linear association of plasma phenylacetylglutamine levels with PSCI at 3 months (\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              for linearity&lt;0.001). Adding plasma phenylacetylglutamine to conventional risk factors significantly improved the risk reclassification of PSCI (net reclassification improvement: 21.35%,\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              =0.019; integrated discrimination index: 1.78%,\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              =0.003). Similar significant findings were observed when PSCI was defined by the Montreal Cognitive Assessment score.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">High plasma phenylacetylglutamine levels were associated with increased odds of PSCI at 3 months, suggesting that plasma phenylacetylglutamine might be a potential predictive biomarker for PSCI among patients with ischemic stroke.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.125.042955","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T11:18:11Z","timestamp":1758280691000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Plasma Phenylacetylglutamine and Cognitive Impairment After Ischemic Stroke"],"prefix":"10.1161","volume":"14","author":[{"given":"Jiawen","family":"Fei","sequence":"first","affiliation":[{"name":"Suzhou Medical College of Soochow University","place":["Jiangsu Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Chang","sequence":"additional","affiliation":[{"name":"Suzhou Medical College of Soochow University","place":["Jiangsu Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences of Soochow University","place":["Suzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"He","sequence":"additional","affiliation":[{"name":"Suzhou Medical College of Soochow University","place":["Jiangsu Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Suzhou 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