{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T17:39:45Z","timestamp":1768930785343,"version":"3.49.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,10,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Current hypertension guidelines recommend intensive blood pressure (BP) targets (eg, &lt;130\/80\u2009mm\u2009Hg) for patients with diabetes and chronic kidney disease. However, data supporting these recommendations are limited.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">From Korean nationwide health screening and claims data, we identified 373\u2009966 adults with both diabetes and chronic kidney disease who (1) underwent a baseline health examination in 2009 to 2013; (2) had \u22653 BP\u2010measuring visits during a 5\u2010year look\u2010back period; and (3) did not have prior cardiovascular disease (CVD). The mean of all BPs measured throughout the look\u2010back period was used for the analysis. The primary outcome was CVD event, defined as a composite of myocardial infarction, stroke, heart failure, or death from CVD.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">Over a median follow\u2010up of 10.2\u2009years, 40\u2009781 CVD events occurred. When using systolic BP 130 to &lt;140\u2009mm\u2009Hg as the reference, multivariable\u2010adjusted hazard ratios (HRs) for CVD event in the systolic BP \u2265150, 140 to &lt;150, 120 to &lt;130, and &lt;120\u2009mm\u2009Hg groups were 1.34 (95% CI, 1.29\u20131.39), 1.11 (95% CI, 1.08\u20131.14), 0.89 (95% CI, 0.87\u20130.91), and 0.77 (95% CI, 0.74\u20130.80), respectively. When using diastolic BP 80 to &lt;90\u2009mm\u2009Hg as the reference, HRs in the diastolic BP \u2265100, 90 to &lt;100, 70 to &lt;80, and &lt;70\u2009mm\u2009Hg groups were 1.70 (95% CI, 1.56\u20131.85), 1.19 (95% CI, 1.15\u20131.24), 0.88 (95% CI, 0.86\u20130.90), and 0.83 (95% CI, 0.80\u20130.87), respectively. Systolic BP &lt;130\u2009mm\u2009Hg and diastolic BP &lt;80\u2009mm\u2009Hg were each associated with reduced CVD risk in a log\u2010linear pattern.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Among patients with diabetes and chronic kidney disease, SBP &lt;130\u2009mm\u2009Hg and diastolic BP &lt;80\u2009mm\u2009Hg were associated with reduced risk of CVD.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.125.042966","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T10:29:52Z","timestamp":1759228192000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Blood Pressure and Cardiovascular Outcomes in Adults With Diabetes and Chronic Kidney Disease"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2895-6835","authenticated-orcid":false,"given":"Hyeok\u2010Hee","family":"Lee","sequence":"first","affiliation":[{"name":"Yonsei University College of Medicine","place":["Seoul, Korea"]},{"name":"Yonsei University","place":["Seoul, Korea"]},{"name":"Harvard Medical School","place":["Boston, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1255-1323","authenticated-orcid":false,"given":"Jong Hyun","family":"Jhee","sequence":"additional","affiliation":[{"name":"Gangnam Severance Hospital, Yonsei University College of Medicine","place":["Seoul, Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun\u2010Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Yonsei University College of Medicine","place":["Seoul, Korea"]},{"name":"Yonsei University","place":["Seoul, Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1491-1937","authenticated-orcid":false,"given":"Dasom","family":"Son","sequence":"additional","affiliation":[{"name":"Yonsei University Graduate School","place":["Seoul, Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7867-1240","authenticated-orcid":false,"given":"Hyeon Chang","family":"Kim","sequence":"additional","affiliation":[{"name":"Yonsei University College of Medicine","place":["Seoul, Korea"]},{"name":"Yonsei University","place":["Seoul, Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6302-8834","authenticated-orcid":false,"given":"Daichi","family":"Shimbo","sequence":"additional","affiliation":[{"name":"Columbia University Irving Medical Center","place":["New York, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5034-8422","authenticated-orcid":false,"given":"Hokyou","family":"Lee","sequence":"additional","affiliation":[{"name":"Yonsei University College of Medicine","place":["Seoul, Korea"]},{"name":"Yonsei University","place":["Seoul, Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(20)30045-3"},{"key":"e_1_3_2_3_2","volume-title":"2022 USRDS Annual Data Report: Epidemiology of Kidney Disease in the United States","author":"United States Renal Data System","year":"2022","unstructured":"United States Renal Data System . 2022 USRDS Annual Data Report: Epidemiology of Kidney Disease in the United States. 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