{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T14:31:27Z","timestamp":1789396287702,"version":"build-2803163510"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"22","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,11,18]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Transthyretin amyloid cardiomyopathy (ATTR\u2010CM) has a specific pathophysiology, with myocardial stiffening and systolic dysfunction only in advanced stages. We aimed to investigate the response to cardiac resynchronization therapy (CRT) in ATTR\u2010CM compared with heart failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">In this multicenter, observational study, patients with ATTR\u2010CM receiving CRT (n=101) were matched to patients without amyloid cardiomyopathy by sex, age, and implantation type (CRT with versus without defibrillator versus conduction system pacing, upgrade versus first implant). We evaluated changes in QRS duration and echocardiographic parameters following CRT implantation and at the most recent available assessments. The study end points were all\u2010cause death alone or combined with heart failure hospitalization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Patients with ATTR\u2010CM (median age, 76 [interquartile range, 72\u201383] years, 98% men, left ventricular (LV) ejection fraction 30% [26\u201333]) showed greater QRS shortening after CRT implantation (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.012), but not after a median of around 1 year (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.152). There were no significant differences in the absolute LV ejection fraction changes immediately after implantation (+7 [+2\/+10] versus +3 [0\/+9] units;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.124), or to the last echo (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.796), which was performed after 1.3\u2009years in patients with ATTR\u2010CM and 2.9\u2009years in patients without amyloid cardiomyopathy. Patients with ATTR\u2010CM had a shorter survival than controls (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001 for both end points). Patients with ATTR\u2010CM experiencing an early improvement in LV ejection fraction had a longer survival (log\u2010rank, 4.3;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.038).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Following CRT implantation, patients with ATTR\u2010CM show QRS narrowing and improvement in LV ejection fraction, not different from patients without amyloid cardiomyopathy. Early favorable LV remodeling seems to be associated with a lower risk of all\u2010cause death.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.043049","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T06:14:51Z","timestamp":1762928091000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Cardiac Resynchronization Therapy, Remodeling, and Outcome in Patients With Amyloid Transthyretin Cardiomyopathy"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9129-9519","authenticated-orcid":false,"given":"Alberto","family":"Aimo","sequence":"first","affiliation":[{"name":"Scuola Superiore Sant\u2019Anna","place":["Pisa, Italy"]},{"name":"Fondazione Toscana Gabriele Monasterio","place":["Pisa, 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USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Bampatsias","sequence":"additional","affiliation":[{"name":"Columbia University","place":["New York City, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7584-2857","authenticated-orcid":false,"given":"Daniela","family":"Tomasoni","sequence":"additional","affiliation":[{"name":"ASST Spedali Civili di Brescia and University of Brescia","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9452-4037","authenticated-orcid":false,"given":"Cinzia","family":"Forleo","sequence":"additional","affiliation":[{"name":"University Hospital of Bari","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3968-4759","authenticated-orcid":false,"given":"Francesco","family":"Musca","sequence":"additional","affiliation":[{"name":"Niguarda 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Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvac119"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2021.07.006"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2020.01.004"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0906431"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.017335"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.13663"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.06.061"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.021612"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab072"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab364"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euaa094"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.016038"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jez072"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-097X.2012.01128.x"}],"container-title":["Journal 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