{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:27:52Z","timestamp":1791329272381,"version":"4.3.1"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"24","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,12,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Chronic kidney disease (CKD) is associated with early menopause, and thereby reduced endogenous estrogen exposure (EEE) and elevated risk of cardiovascular disease (CVD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Included were 138\u2009154 naturally menopausal and 63\u2009542 nonmenopausal women from the UK Biobank. To reflect cumulative EEE, duration of EEE was estimated as the time interval between age at menarche and current age (for nonmenopausal women) or age at menopause (for menopausal women). The relationship of menopausal status with incident CVD were assessed by CKD status, further considering cumulative EEE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Menopausal and nonmenopausal women had a comparable risk of CVD after accounting for age. Menopausal status interacted with CKD on risk of CVD (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      for interaction=0.001). In the CKD group, menopausal women had a lower risk of CVD than nonmenopausal women (hazard ratio [HR], 0.75 [95% CI, 0.58\u20130.97]), predominantly for those with EEE \u226538\u2009years (HR, 0.64 [95% CI, 0.47\u20130.88]) but not for those with shorter EEE (HR, 1.00). In the non\u2010CKD group, being menopausal was not associated with risk of CVD (HR, 1.00), but was associated with a suggestively lower risk among those with longer EEE (HR, 0.90 [95% CI, 0.81\u20131.00]) and a higher risk among those with shorter EEE (HR, 1.13 [95% CI, 1.02\u20131.25).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">The association of menopausal status with risk of CVD appears to be varied by CKD status and further influenced by cumulative exposure to endogenous estrogen. These findings may have implications for more individualized CVD risk stratification and prevention in menopausal women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.043102","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T12:06:06Z","timestamp":1764763566000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Influence of Chronic Kidney Disease on the Relationship Between Menopausal Status and Major Cardiovascular Disease in Women"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-8954-6162","authenticated-orcid":false,"given":"Wen\u2010Wen","family":"Han","sequence":"first","affiliation":[{"name":"Suzhou Medical College of Soochow University","place":["Suzhou, China"]},{"name":"Suzhou Medical College of Soochow University","place":["Suzhou, 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