{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:45:06Z","timestamp":1782992706418,"version":"3.54.5"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,3,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">More young women than men experience first\u2010time strokes. This may be from improved detection of milder severity strokes in young women, as they are more likely to present with nondebilitating neurologic symptoms than men.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">The objective was to examine sex differences in stroke severity among young adults. Young adults (18\u201355) with index stroke (January 1, 2012\u2013April 3, 2019) were identified, using Colorado All Payer's Claims Database and linked to the GWTG (Get With The Guidelines)\u2010Stroke Registry. Records were reviewed based on 5\/5 linked identifiers (\u00b11 day for admission\/discharge dates, date of birth, sex, and hospital), then on 4\/5 linked identifiers. Stroke severity based on National Institutes of Health Stroke Scale score was extracted from GWTG\u2010stroke. Logistic regression models were used to calculate odds ratios (OR) of having a mild severity stroke (National Institutes of Health Stroke Scale score \u22645) by sex in ages 18 to 45 and 46 to 55 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Colorado All Payer's Claims Database captured 3029 stroke cases; 2732 from hospitals that reported to GWTG\u2010Stroke; 1597 (58.7%) linked at least 4\/5 identifiers; 1311 with National Institutes of Health Stroke Scale score (50.2% women, 80% ischemic). Women were younger (mean age 45.4 years, men 46.9 years,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.001), had lower blood pressure (median 143\/85, men 150\/91,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001), and lower proportion without nontraditional risk factors (16.7%, men 29.0%,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). No sex differences in stroke severity were observed for all strokes (OR 18\u201345, 1.10 [95% CI, 0.74\u20131.61]; OR, 46\u201355, 0.80 [95% CI, 0.59\u20131.09]). Women aged 18 to 45 years experienced more mild severity hemorrhagic strokes (OR, 2.94 [95% CI, 1.18\u20137.69],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.02) but not in 46\u201355 (OR, 1.02 [95% CI, 0.5\u20132.08]). There was no difference in ischemic stroke severity by sex in either age group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Young women with index strokes did not present with more milder severity strokes compared with men.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.043159","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T10:25:48Z","timestamp":1772101548000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Sex Differences in Young Adult Stroke Severity Using Linked Colorado\u2014All Payer's Claims Database and the Get With The Guidelines\u2010Stroke 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