{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T19:40:36Z","timestamp":1793302836979,"version":"4.5.0"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,5,5]]},"abstract":"\n Background<\/jats:title>\n \n Von Willebrand factor (VWF) and ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif, 13) are linked to dementia risk, and limited evidence suggests\n apolipoprotein E<\/jats:italic>\n (\n APOE<\/jats:italic>\n )\u2010\u03b54 alters VWF release. This study assessed whether baseline VWF and ADAMTS13 levels predict neurodegeneration and cognitive decline and evaluated effect modification by\n APOE\u2010\u03b54<\/jats:italic>\n carriership.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Vanderbilt Memory and Aging Project cohort participants (n=332, 73\u00b17\u2009years, 59% male) completed serial blood draw, neuropsychological assessment, and brain magnetic resonance imaging over 6.4\u2009years (range 1.4\u20139.7\u2009years). Baseline plasma VWF and ADAMTS13 levels were quantified using mass spectrometry and Olink. Fully adjusted linear mixed\u2010effects models related\n protein\u00d7time<\/jats:italic>\n and\n protein\u00d7APOE\u2010\u03b54\u00d7time<\/jats:italic>\n interaction terms to longitudinal brain magnetic resonance imaging and neuropsychological outcomes.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Lower baseline ADAMTS13 predicted faster declines in language (\u03b2=0.11,\n P<\/jats:italic>\n =0.01), information processing speed (\u03b2=0.27,\n P<\/jats:italic>\n =0.001), executive function (\u03b2=0.01,\n P<\/jats:italic>\n =0.03), episodic memory (\u03b2=0.01,\n P<\/jats:italic>\n =0.03), and visuospatial ability (\u03b2=0.11,\n P<\/jats:italic>\n =0.001) and faster increases in global (\u03b2=\u22120.29,\n P<\/jats:italic>\n =0.01) and frontal (\u03b2=\u22120.17,\n P<\/jats:italic>\n =0.01) white matter hyperintensity volumes. Associations between ADAMTS13 and faster rates of cognitive decline and white matter injury were driven by\n APOE<\/jats:italic>\n \u2010\u03b54 carriers. Models relating VWF to longitudinal outcomes were null.\n APOE<\/jats:italic>\n \u2010\u03b54 interacted with VWF on longitudinal gray matter volumetric outcomes, such that faster rates of global gray matter atrophy were observed with higher baseline VWF levels among\n APOE<\/jats:italic>\n \u2010\u03b54 noncarriers only (\u03b2=\u22121530.5,\n P<\/jats:italic>\n <0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n ADAMTS13 shows promise as a potential plasma biomarker for brain aging outcomes, but additional research is warranted to understand the performance of VWF in the presence versus absence of an\n APOE<\/jats:italic>\n \u2010\u03b54 allele.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.125.043186","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T09:57:17Z","timestamp":1776679037000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Plasma von Willebrand Factor and ADAMTS13 Interact With\n APOE<\/i>\n \u2010\u03b54 in Predicting Longitudinal Brain Atrophy and Cognitive Decline Over a 9\u2010Year Follow\u2010Up"],"prefix":"10.1161","volume":"15","author":[{"given":"Hailey A.","family":"Adegboye","sequence":"first","affiliation":[{"name":"Vanderbilt University School of Medicine","place":["Nashville, USA"]},{"name":"Vanderbilt University School of Medicine","place":["Nashville, USA"]},{"name":"Vanderbilt University School of Medicine","place":["Nashville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyi","family":"Sun","sequence":"additional","affiliation":[{"name":"Vanderbilt University School of Medicine","place":["Nashville, USA"]},{"name":"Vanderbilt University Medical Center","place":["Nashville, 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