{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:49:21Z","timestamp":1791395361389,"version":"4.3.3"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"24","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,12,16]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Patients with heart failure (HF) have a significantly higher prevalence of cognitive impairment than those without HF. While the association of dementia with prognosis of patients with HF is well documented in Western populations, data from large, prospective cohorts in East Asia, particularly Japan, remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">The KCHF (Kyoto Congestive Heart Failure) registry, a prospective cohort study, enrolled consecutive patients admitted for acute decompensated HF in Japan. We evaluated 3728 patients who were alive at discharge and for whom follow\u2010up data were available. We compared 1\u2010year clinical outcomes between patients with and without dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Of 3728 participants, 658 (17.6%) were diagnosed with dementia. Patients with dementia were older, more likely to be men, more often had atrial fibrillation and prior stroke with poorer daily life activities and poor adherence to medical therapy, and less often received guideline\u2010directed medications at discharge than those without dementia. After adjustment for confounders, the excess risk of patients with dementia compared with those without dementia remained significant for all\u2010cause death and cardiovascular death (hazard ratio [HR], 1.45 [95% CI, 1.17\u20131.79];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.0007; HR, 1.48 [95% CI, 1.12\u20131.95];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.006, respectively). However, the excess risk of patients with dementia compared with those without dementia was no longer significant for noncardiovascular death and HF hospitalization (HR, 1.36 [95% CI, 0.96\u20131.91];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.08; HR, 1.08 [95% CI, 0.88\u20131.33];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.45, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Dementia in patients with HF is associated with the risk for all\u2010cause death as well as cardiovascular death.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.043203","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T12:07:02Z","timestamp":1764763622000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Association of Dementia With the Outcome of Patients With Heart Failure: Evidence From the Japanese KCHF Registry"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0022-9537","authenticated-orcid":false,"given":"Erika","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Kyoto University Graduate School of Medicine","place":["Kyoto, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8213-7999","authenticated-orcid":false,"given":"Takao","family":"Kato","sequence":"additional","affiliation":[{"name":"Kyoto University Graduate School of Medicine","place":["Kyoto, 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