{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:51:15Z","timestamp":1788954675532,"version":"build-2803163510"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,10,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Guidelines for lipid\u2010lowering therapy in patients with dialysis\u2010dependent chronic kidney disease remain ambiguous. We aimed to explore cardiovascular outcomes associated with statin use in patients with hemodialysis\u2010dependent chronic kidney disease, stratified by prior statin use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">This was a retrospective cohort study of patients with chronic kidney disease who initiated maintenance hemodialysis, using a nationwide health claims database in Korea between 2010 and 2021. A multivariate Cox regression analysis was performed, incorporating statin use throughout the follow\u2010up period as a time\u2010dependent variable. The primary outcome was a composite of stroke, myocardial infarction, and all\u2010cause mortality. A subgroup analysis was conducted based on statin use before hemodialysis initiation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Of the 49\u2009868 study participants, the mean age at hemodialysis initiation was 65.5\u00b111.2\u2009years, and 32\u2009225 (64.6%) were men. During a mean follow\u2010up of 3.8\u2009years, the primary composite outcome occurred in 20\u2009345 patients (40.8%). Throughout the follow\u2010up period, approximately 40% of patients received statin therapy. Statin use was significantly associated with a reduced risk of the primary composite outcome (adjusted hazard ratio, 0.51 [95% CI, 0.49\u20130.53];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). This association was consistent regardless of prior statin use, although the benefit was less pronounced in statin\u2010na\u00efve patients (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      for interaction &lt;0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Statin use was consistently associated with improved long\u2010term cardiovascular outcomes in patients with hemodialysis\u2010dependent chronic kidney disease, regardless of prior statin use. These findings suggest that continuing statin therapy is crucial for cardiovascular prevention in patients already receiving statins before hemodialysis initiation; initiating statin therapy may also provide clinical benefits in statin\u2010na\u00efve patients undergoing hemodialysis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.043214","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T03:15:54Z","timestamp":1761102954000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of Statins in Patients With Hemodialysis\u2010Dependent Chronic Kidney Disease: A Nationwide Cohort Study"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6582-0953","authenticated-orcid":false,"given":"Minyoul","family":"Baik","sequence":"first","affiliation":[{"name":"Yonsei University College of Medicine","place":["Yongin\u2010si, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1497-3914","authenticated-orcid":false,"given":"Jimin","family":"Jeon","sequence":"additional","affiliation":[{"name":"Yonsei University College of Medicine","place":["Yongin\u2010si, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1169-6798","authenticated-orcid":false,"given":"Joonsang","family":"Yoo","sequence":"additional","affiliation":[{"name":"Yonsei University College of Medicine","place":["Yongin\u2010si, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0156-9736","authenticated-orcid":false,"given":"Jinkwon","family":"Kim","sequence":"additional","affiliation":[{"name":"Yonsei University College of Medicine","place":["Yongin\u2010si, South 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