{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T06:48:08Z","timestamp":1784616488683,"version":"3.55.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,11,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Limited data support the link between dual antiplatelet therapy (DAPT) and adverse outcome among patients with intracerebral hemorrhage. This study aimed to investigate the association between prior use of DAPT and mortality after intracerebral hemorrhage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Patients with first\u2010ever intracerebral hemorrhage on current APT at the time of admission, were identified and followed 180\u2009days after admission through the Danish nationwide registries. Prior exposure to DAPT or single APT (SAPT) was established through the Danish National Prescription Registry. Inverse probability of treatment weighting was used to control for confounding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      A total of 5800 patients were on antiplatelet therapy. 5535 (95.4%) were on SAPT, and 265 (4.6%) were on DAPT. Compared with patients on SAPT, patients on DAPT more commonly had a history of ischemic stroke or transient ischemic attack (134 [50.6%] versus 2393 [43.2%]), ischemic heart disease (172 [64.9%] versus 1561 [28.2%]), congestive heart failure (57 [21.5%] versus 505 [9.1%]) or chronic kidney disease (25 [9.4%] versus 205 [3.7%]). The 180\u2010day cumulative mortality rate was 52.6% for patients on DAPT and 45.6% for patients on SAPT (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.004). After weighting and compared with SAPT, prior use of DAPT was associated with a 43% higher mortality risk at day 1 (weighted risk ratio 1.43, 95% CI, 1.13\u20131.82). Higher early mortality among patients on DAPT was found to be the driving force behind the higher day 180 mortality in this group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Among patients with intracerebral hemorrhage, prior DAPT was found to be associated with a higher mortality compared with SAPT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.043268","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:51:03Z","timestamp":1761648663000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Prior Dual Antiplatelet Therapy and Mortality After Intracerebral Hemorrhage: A Danish Nationwide Cohort Study"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4870-4475","authenticated-orcid":false,"given":"Christian","family":"Ovesen","sequence":"first","affiliation":[{"name":"Odense University Hospital","place":["Odense, Denmark"]},{"name":"University of Southern Denmark","place":["Odense, Denmark"]},{"name":"Bispebjerg Hospital, University Hospital of Copenhagen","place":["Copenhagen, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Alberto","family":"Garc\u00eda Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Centro Espa\u00f1ol Investigaci\u00f3n Farmacoepidemiol\u00f3gica","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8097-8708","authenticated-orcid":false,"given":"Jesper","family":"Hallas","sequence":"additional","affiliation":[{"name":"University of Southern Denmark","place":["Odense, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Storm","sequence":"additional","affiliation":[{"name":"Odense University Hospital","place":["Odense, Denmark"]},{"name":"University of Southern Denmark","place":["Odense, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1600-1684","authenticated-orcid":false,"given":"Stine Munk","family":"Hald","sequence":"additional","affiliation":[{"name":"Odense University Hospital","place":["Odense, Denmark"]},{"name":"University of Southern Denmark","place":["Odense, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0858-4269","authenticated-orcid":false,"given":"S\u00f6ren","family":"M\u00f6ller","sequence":"additional","affiliation":[{"name":"University of Southern Denmark","place":["Odense, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1936-3173","authenticated-orcid":false,"given":"Magdy","family":"Selim","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center, Harvard Medical School","place":["Boston, USA"]},{"name":"Research Unit for Neurology Odense University Hospital and University of Southern Denmark","place":["Odense, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5205-7007","authenticated-orcid":false,"given":"David","family":"Gaist","sequence":"additional","affiliation":[{"name":"Odense University Hospital","place":["Odense, Denmark"]},{"name":"University of Southern Denmark","place":["Odense, 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