{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T20:07:32Z","timestamp":1787947652309,"version":"build-2784847793"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,5,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Postoperative vasoplegia syndrome (PVS) following cardiac surgery has previously been associated with poor survival. This study aimed to investigate outcomes and predictors of PVS following left ventricular assist device implantation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">This was a retrospective study of 190 left ventricular assist device recipients at The Ohio State University. Primary outcomes included hospitalization duration, right\u2010sided heart failure, and mortality. Risk factor evaluation included multivariate analysis of cardiovascular comorbidities and perioperative medication use. Patients were stratified into PVS (n=50, 26.3%) and non\u2010PVS cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      On univariate analysis, PVS was associated with male sex (94% versus 67%,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.0004) and higher body mass index (32.5 versus 29.0,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.0011). Further, PVS was associated with diabetes (60.0% versus 41.4%,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.036), higher preoperative hemoglobin A\n                      <jats:sub>1c<\/jats:sub>\n                      levels (6.8% versus 6.3%,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.0354), and higher rates of microvascular complications (28.0% versus 12.9%,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.014). Preoperatively, patients without PVS were more likely to receive dobutamine (58.6% versus 34.0%,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.004) and at higher dosages (2.9 versus 1.9\u2009\u03bcg\/kg\u2009per\u2009min,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.0196). Primary outcomes, including mortality, were similar between groups. Multivariate analysis demonstrated male sex (odds ratio [OR], 9.43 [95% CI, 2.93\u201343.6]) and higher body mass index (OR, 1.11, [95% CI, 1.04\u20131.18]) as independent risk factors. HeartMate 3 implantation (OR, 0.33 [95% CI, 0.10\u20130.97]) and preimplant dobutamine infusion (OR, 0.28 [95% CI, 0.12\u20130.61]) were protective factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">PVS did not confer inferior outcomes after left ventricular assist device implantation but was associated with male sex and higher body mass index. Preoperative dobutamine was more commonly used in patients without PVS, warranting further investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.043366","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T09:56:40Z","timestamp":1776679000000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Outcomes and Risk Factors for Postoperative Vasoplegia Following Implant of Left Ventricular Assist Devices"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4088-7235","authenticated-orcid":false,"given":"Jonathan C.","family":"Wright","sequence":"first","affiliation":[{"name":"The Ohio State University Wexner Medical Center","place":["Columbus, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jameson G.","family":"Wilbur","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical 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