{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T12:10:48Z","timestamp":1780488648893,"version":"3.54.1"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,11,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Many patients undergoing transcatheter aortic valve implantation (TAVI) have an indication for oral anticoagulation (OAC). Our aim was to study sex differences in outcomes after TAVI, depending on the type and regimen of vitamin K antagonist versus direct OAC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">The Popular PAUSE TAVI (Periprocedural Continuation Versus Interruption of Oral Anticoagulant Drugs During Transcatheter Aortic Valve Implantation) was a randomized clinical trial to compare outcomes between patients who continued or interrupted OAC during TAVI. The outcomes of interest in this subanalysis were a combination of cardiovascular mortality, stroke, myocardial infarction, major vascular complications or major bleeding at 30\u2009days, stratified by OAC regimen and type, and sex.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      After 30\u2009days of follow\u2010up, 44\/296 (14.9%) women reached the combined end point, compared with 90\/562 men (16.0%),\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.732. There were no statistically significant differences between sexes in outcomes, irrespective of the continued or interrupted OAC regimen. Women on vitamin K antagonist had a numerically higher combined event rate (21.7%) compared with women using direct OAC (13.1%), although not statistically significant (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.146), similarly for major vascular complications (15% versus 7.2% in women on vitamin K antagonist and direct OAC respectively [\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.255]). The interaction between sex and type of OAC for the combined end point lost significance after correcting for OAC indication and randomization, among others (unadjusted:\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.037, adjusted=0.090).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">After a 30\u2010day follow\u2010up of patients undergoing TAVI on OAC, there were no statistically significant differences in outcomes between sexes, independent of interrupted or continued management. Although women treated with vitamin K antagonist had numerically more events than those with direct OAC and an interaction between sex and type of OAC was present, this interaction lost significance after adjustment for other factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT04437303\">https:\/\/clinicaltrials.gov\/study\/NCT04437303<\/jats:ext-link>\n                      ; Unique Identifier: NCT044373030.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.043448","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T11:12:05Z","timestamp":1761217925000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Sex Differences in Transcatheter Aortic Valve Implantation Outcomes in Patients on Oral Anticoagulants: A Popular PAUSE TAVI SubAnalysis"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6271-0567","authenticated-orcid":false,"given":"Kees H.","family":"van Bergeijk","sequence":"first","affiliation":[{"name":"University of Groningen, University Medical Center Groningen","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dani\u00ebl C.","family":"Overduin","sequence":"additional","affiliation":[{"name":"St. Antonius Hospital","place":["Nieuwegein, the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6273-9287","authenticated-orcid":false,"given":"Constantijn S.","family":"Venema","sequence":"additional","affiliation":[{"name":"University of Groningen, University Medical Center Groningen","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk Jan","family":"van Ginkel","sequence":"additional","affiliation":[{"name":"St. Antonius Hospital","place":["Nieuwegein, the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5441-2668","authenticated-orcid":false,"given":"Hindrik W.","family":"van der Werf","sequence":"additional","affiliation":[{"name":"University of Groningen, University Medical Center Groningen","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0385-0524","authenticated-orcid":false,"given":"Ad F. M.","family":"van den Heuvel","sequence":"additional","affiliation":[{"name":"University of Groningen, University Medical Center Groningen","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5417-4415","authenticated-orcid":false,"given":"Adriaan A.","family":"Voors","sequence":"additional","affiliation":[{"name":"University of Groningen, University Medical Center Groningen","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7577-4084","authenticated-orcid":false,"given":"Joanna J.","family":"Wykrzykowska","sequence":"additional","affiliation":[{"name":"University of Groningen, University Medical Center Groningen","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5192-886X","authenticated-orcid":false,"given":"Jurrien M.","family":"Ten Berg","sequence":"additional","affiliation":[{"name":"St. Antonius Hospital","place":["Nieuwegein, the Netherlands"]},{"name":"Cardiovascular Research Institute Maastricht (CARIM)","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2016.12.001"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.05.035"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.11.008"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.10.011"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2018.08.036"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2407794"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2021.02.066"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","unstructured":"Kodali S Williams MR Doshi D Hahn RT Humphries KH Nkomo VT Cohen DJ Douglas PS Mack M Xu K et\u00a0al. 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