{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T04:59:00Z","timestamp":1789275540670,"version":"build-2803163510"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,10,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">The Prognostic Nutritional Index (PNI) as an indicator of nutritional and immunological status has been widely applied in various medical conditions. However, its prognostic role in postoperative outcomes after coronary artery bypass grafting has not been fully elucidated. This study investigated the long\u2010term prognostic impact of PNI for patients undergoing coronary artery bypass grafting.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              A total of 6626 patients who underwent coronary artery bypass grafting from 2001 to 2017 were analyzed.\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">PNI<\/jats:styled-content>\n              was calculated as 10\u00d7serum albumin (g\/\n              <jats:styled-content style=\"fixed-case\" toggle=\"no\">dL<\/jats:styled-content>\n              )+0.005\u00d7total lymphocyte count (per mm\n              <jats:sup>3<\/jats:sup>\n              ).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              PNI is negatively correlated with age (\n              <jats:italic toggle=\"no\">r<\/jats:italic>\n              =\u22120.24,\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              &lt;0.001) and positively correlated with body mass index (\n              <jats:italic toggle=\"no\">r<\/jats:italic>\n              =0.13,\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              &lt;0.001). PNI was significantly associated with all\u2010cause mortality during a median follow\u2010up of 10.0\u2009years (hazard ratio [HR], 0.96 [per 1 increase] [95% CI, 0.96\u20130.97];\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              &lt;0.001). The low\u2010PNI group (\u226447, n=3956) showed a higher incidence of all\u2010cause mortality than those with high PNI (&gt;47, n=2670) (64.8% versus 45.5%; adjusted HR, 1.19 [95% CI, 1.09\u20131.30];\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              &lt;0.001). The model including PNI showed better prognostic discrimination for predicting all\u2010cause mortality during long\u2010term follow\u2010up compared with the model with only clinical variables (C index, 0.733 [95% CI, 0.721\u20130.745] versus 0.763 [95% CI, 0.751\u20130.774]; integrated discrimination improvement, 0.037 [95% CI, 0.032\u20130.042]; net reclassification index, 0.334 [95% CI, 0.286\u20130.383];\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              &lt;0.001 for each comparison).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Perioperative PNI was significantly associated with long\u2010term mortality after coronary artery bypass grafting, and addition of PNI improved risk discrimination beyond conventional clinical models. Further prospective studies are warranted to validate these findings.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.125.043597","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T10:33:56Z","timestamp":1759228436000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Long\u2010Term Prognostic Value of the Prognostic Nutritional Index in Patients Undergoing Coronary Artery Bypass Grafting"],"prefix":"10.1161","volume":"14","author":[{"given":"Dong Hyun","family":"Gim","sequence":"first","affiliation":[{"name":"Samsung Medical Center, Sungkyunkwan University School of Medicine","place":["Seoul, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2337-7826","authenticated-orcid":false,"given":"Seung Hun","family":"Lee","sequence":"additional","affiliation":[{"name":"Chonnam National University Hospital, Chonnam National University Medical School","place":["Gwangju, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9363-8600","authenticated-orcid":false,"given":"Ji Hyun","family":"Cha","sequence":"additional","affiliation":[{"name":"Samsung Medical Center, Sungkyunkwan University School of Medicine","place":["Seoul, South Korea"]},{"name":"Samsung Medical Center, Sungkyunkwan University School of Medicine","place":["Seoul, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7511-9581","authenticated-orcid":false,"given":"Ki Hong","family":"Choi","sequence":"additional","affiliation":[{"name":"Samsung Medical Center, Sungkyunkwan University School of Medicine","place":["Seoul, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3986-9152","authenticated-orcid":false,"given":"Young Bin","family":"Song","sequence":"additional","affiliation":[{"name":"Samsung Medical Center, Sungkyunkwan University School of Medicine","place":["Seoul, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2178-4014","authenticated-orcid":false,"given":"Joo Myung","family":"Lee","sequence":"additional","affiliation":[{"name":"Samsung Medical Center, Sungkyunkwan University School of Medicine","place":["Seoul, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1440-3583","authenticated-orcid":false,"given":"Taek Kyu","family":"Park","sequence":"additional","affiliation":[{"name":"Samsung Medical Center, Sungkyunkwan University School of Medicine","place":["Seoul, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo\u2010Yong","family":"Hahn","sequence":"additional","affiliation":[{"name":"Samsung Medical Center, Sungkyunkwan University School of Medicine","place":["Seoul, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung\u2010Hyuk","family":"Choi","sequence":"additional","affiliation":[{"name":"Samsung Medical Center, Sungkyunkwan University School of Medicine","place":["Seoul, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4902-5634","authenticated-orcid":false,"given":"Hyeon\u2010Cheol","family":"Gwon","sequence":"additional","affiliation":[{"name":"Samsung Medical Center, Sungkyunkwan University School of Medicine","place":["Seoul, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6947-8403","authenticated-orcid":false,"given":"Dong Seop","family":"Jeong","sequence":"additional","affiliation":[{"name":"Samsung Medical Center, Sungkyunkwan University School of Medicine","place":["Seoul, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Ryeun","family":"Chung","sequence":"additional","affiliation":[{"name":"Samsung Medical Center, Sungkyunkwan University School of Medicine","place":["Seoul, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang Hyun","family":"Cho","sequence":"additional","affiliation":[{"name":"Samsung Medical Center, Sungkyunkwan University School of Medicine","place":["Seoul, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiick","family":"Sung","sequence":"additional","affiliation":[{"name":"Samsung Medical Center, Sungkyunkwan University School of Medicine","place":["Seoul, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wook Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Samsung Medical Center, Sungkyunkwan University School of Medicine","place":["Seoul, South 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