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However, the signals and transcriptional events driving the proliferation of atheroma macrophages remain poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Transcriptomic and histological analysis of human plaque spanning a range of disease severity and in\u00a0vitro models of macrophage function was conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Transcriptomic analyses identified a subpopulation of macrophages that expressed the hematopoietic transcription factor GATA2. These GATA2\u2010expressing macrophages had a transcriptional profile that was intermediary between monocytes and mature macrophages and selectively upregulated genes associated with proliferation and apoptosis. The expression of GATA2 was concomitant with plaque macrophage proliferation at all stages of disease but not macrophage proliferation in other tissues, with &gt;90% of proliferating atheroma macrophages expressing GATA2. GATA2 was upregulated in macrophages following exposure to oxidized low\u2010density lipoprotein, with GATA2 expression being necessary and sufficient for the proliferation of these macrophages. In these cells, GATA2 mediates proliferation by upregulating expression of the protooncogene MYB, while simultaneously decreasing sensitivity to apoptosis induced by the unfolded protein response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Together, these data identify GATA2 as a transcription factor upregulated by atherogenic stimuli that functions as the primary mediator of macrophage proliferation in atherosclerotic plaque.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.043646","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:52:15Z","timestamp":1761648735000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["GATA2 Mediates Macrophage Proliferation During 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