{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T07:25:52Z","timestamp":1793258752056,"version":"4.5.0"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,5,19]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The low\u2010density lipoprotein cholesterol (LDL\u2010C)\u2010lowering effect of inclisiran, a proprotein convertase subtilisin\/kexin type 9\u2010targeting small interfering RNA, has not been established in patients with recent acute coronary syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">VICTORION\u2010INCEPTION, a 330\u2010day, phase 3b, open\u2010label, multicenter trial, designed to mimic clinical practice, randomized 400 eligible participants (discharged following acute coronary syndrome \u22645\u2009weeks of screening, with LDL\u2010C \u226570\u2009mg\/dL [or non\u2013high\u2010density lipoprotein cholesterol \u2265100\u2009mg\/dL], receiving statin therapy or statin intolerant) 1:1 to inclisiran sodium 300\u2009mg (284 mg inclisiran equivalent; Days 0, 90, 270)\u2009+\u2009usual care, or usual care (clinician\u2010directed LDL\u2010C management). Coprimary end points at Day 330 were LDL\u2010C &lt;70\u2009mg\/dL attainment and LDL\u2010C percentage change from baseline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      At Day 90, inclisiran + usual care led to greater LDL\u2010C goal attainment and lowering versus usual care (&lt;70\u2009mg\/dL: 74.6% versus 26.6%, odds ratio [OR], 10.84 [97.5% CI, 6.13\u201319.16]; &lt;55\u2009mg\/dL: 63.2% versus 8.5%, OR, 26.58 [95% CI, 14.14\u201349.98]; percentage change from baseline: \u221248.9% versus 2.2%); this was sustained to Day 330 (&lt;70\u2009mg\/dL: 66.7% versus 28.1%, OR, 5.42 [97.5% CI, 3.29\u20138.91],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001; &lt;55\u2009mg\/dL: 54.2% versus 13.6%, OR, 8.24 [95% CI, 4.97\u201313.65]; percentage change: \u221246.9% difference [97.5% CI, \u221255.4 to \u221238.5];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). Participants with \u22651 adverse events were comparable (inclisiran + usual care, 58.6%; usual care, 53.3%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">VICTORION\u2010INCEPTION was the first inclisiran trial in participants with recent acute coronary syndrome. Early inclisiran initiation with usual care resulted in rapid, sustained attainment of guideline\u2010directed LDL\u2010C goals and was well tolerated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT04873934\">https:\/\/clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT04873934.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.043655","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T11:13:37Z","timestamp":1778757217000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Low\u2010Density Lipoprotein Cholesterol Lowering With Inclisiran Plus Usual Care in Recent Acute Coronary Syndrome: VICTORION\u2010INCEPTION, a Randomized, Controlled, Open\u2010Label Trial"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3544-4130","authenticated-orcid":false,"given":"Kirk U.","family":"Knowlton","sequence":"first","affiliation":[{"name":"Intermountain Medical Center Heart Institute","place":["Murray, USA"]},{"name":"University of Utah","place":["Salt Lake City, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6197-9860","authenticated-orcid":false,"given":"Ann 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