{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T06:40:51Z","timestamp":1787640051618,"version":"build-2736575974"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,2,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Neutrophil extracellular traps are released from activated neutrophils and are involved in the pathogenesis of atherosclerotic lesions, atherothrombosis, and myocardial injury. We investigated the prognostic value of circulating neutrophil extracellular trap biomarkers in patients with suspected acute coronary syndrome (ACS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">A total of 1482 patients admitted with suspected non\u2013ST\u2010segment elevation ACS were included and followed for a median of 4.2\u2009years. The primary end point was a composite of death from any cause, incident myocardial infarction and hospitalization for heart failure. Secondary end points were all\u2010cause mortality, cardiovascular death, incident myocardial infarction, hospitalization for heart failure, and new\u2010onset atrial fibrillation. Admission blood samples were analyzed for the neutrophil extracellular trap biomarkers double\u2010stranded DNA (dsDNA), CitH3 (citrullinated histone H3), and myeloperoxidase\u2010DNA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      A doubling of dsDNA concentration was associated with a hazard ratio (HR) of 3.11 (95% CI, 1.61\u20135.98,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001) for the primary end point after adjusting for traditional risk factors, cardiac troponin T and N\u2010terminal pro\u2010B\u2010type natriuretic peptide. DsDNA served as a prognostic marker both in patients with (adjusted HR, 5.33 [95% CI, 1.67\u201317.06],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.005) and without ACS (adjusted HR, 2.86 [95% CI, 1.30\u20136.28],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.009). In contrast, CitH3 and myeloperoxidase\u2010DNA showed no significant prognostic value.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In patients with suspected ACS, dsDNA emerged as a long\u2010term prognostic marker for a composite outcome of death, incident myocardial infarction, or heart failure hospitalization, independent of conventional risk factors. DsDNA can independently from established risk factors identify high\u2010risk patients with and without ACS who may benefit from risk reduction.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.043680","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T11:03:17Z","timestamp":1770807797000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Circulating Markers of Neutrophil Extracellular Traps for Long\u2010Term Prognosis in Patients With Acute Chest Pain"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4885-1085","authenticated-orcid":false,"given":"Gard Mikael S\u00e6le","family":"Myrmel","sequence":"first","affiliation":[{"name":"Haukeland University Hospital","place":["Bergen, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5012-9214","authenticated-orcid":false,"given":"Ragnhild","family":"Helseth","sequence":"additional","affiliation":[{"name":"Oslo University Hospital","place":["Oslo, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2520-9436","authenticated-orcid":false,"given":"Ole Thomas","family":"Steiro","sequence":"additional","affiliation":[{"name":"Haukeland University Hospital","place":["Bergen, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2577-5497","authenticated-orcid":false,"given":"Hilde Lunde","family":"Tjora","sequence":"additional","affiliation":[{"name":"Haukeland University Hospital","place":["Bergen, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rund","family":"Lang\u00f8rgen","sequence":"additional","affiliation":[{"name":"Haukeland University Hospital","place":["Bergen, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6637-5743","authenticated-orcid":false,"given":"Rune Oskar","family":"Bj\u00f8rneklett","sequence":"additional","affiliation":[{"name":"Haukeland University Hospital","place":["Bergen, Norway"]},{"name":"University of Bergen","place":["Bergen, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2775-4219","authenticated-orcid":false,"given":"Vibeke","family":"Bratseth","sequence":"additional","affiliation":[{"name":"Oslo University Hospital","place":["Oslo, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8130-107X","authenticated-orcid":false,"given":"Sheryl","family":"Palmero","sequence":"additional","affiliation":[{"name":"Oslo University Hospital","place":["Oslo, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9502-6841","authenticated-orcid":false,"given":"Ida Gjervold","family":"Lunde","sequence":"additional","affiliation":[{"name":"Oslo University Hospital","place":["Oslo, Norway"]},{"name":"Institute of Clinical Medicine, University of Oslo","place":["Oslo, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine Lovise M\u00f8rk","family":"Kindberg","sequence":"additional","affiliation":[{"name":"Oslo University Hospital","place":["Oslo, Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4794-6269","authenticated-orcid":false,"given":"Kjell","family":"Vikenes","sequence":"additional","affiliation":[{"name":"Haukeland University Hospital","place":["Bergen, Norway"]},{"name":"University of Bergen","place":["Bergen, 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