{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T19:20:57Z","timestamp":1793906457652,"version":"4.8.0"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,11,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Traditional East Asian medicine (TM) is widely used in Korea and other East Asian countries. However, the effects of TM treatment on acute ischemic stroke (AIS) outcomes remain unclear, as previous studies lacked a sufficient sample size, a consecutive series design, or a prospective outcome capture approach. We aimed to investigate whether combining TM with conventional Western medicine (CM) treatments (C+TM) leads to better outcomes after AIS, relative to CM treatment alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We retrospectively analyzed 2157 consecutive patients with AIS from a prospectively collected registry (2011\u20132021) at our center and compared the CM and C+TM groups in terms of demographics and clinical efficacy, including a 3\u2010month favorable functional outcome (modified Rankin scale score \u22641) by performing modified Poisson regression analysis, with inverse probability of treatment weighting to balance key clinical and demographic variables, as the main analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Mean age was 66.7\u00b112.8\u2009years, and 63.5% were men. Compared with patients in the CM group (n=1750), those in the C+TM group (n=407) were more likely to be women, have higher admission National Institutes of Health Stroke Scale scores, present more frequently with strokes due to large\u2010arteryatherosclerosis or small\u2010vessel occlusion, and have a lower prevalence of smoking history. C+TM treatment was associated with a ~40% significantly lower rate of 3\u2010month favorable functional outcome (adjusted relative risk [RR], 0.60 [95% CI, 0.51\u20130.70]; RR, 0.62 [95% CI, 0.53\u20130.72] after inverse probability of treatment weighting; both\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001) compared with CM treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">TM, when integrated into CM care, may be linked to less favorable functional outcomes after AIS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.043784","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:48:18Z","timestamp":1761648498000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Combining Traditional East Asian and Conventional Western Medicine on Acute Stroke Outcomes"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7850-0804","authenticated-orcid":false,"given":"Dong\u2010Seok","family":"Gwak","sequence":"first","affiliation":[{"name":"Dongguk University Ilsan Hospital","place":["Goyang, Republic of Korea"]},{"name":"National Priority Research Center for Stroke","place":["Goyang, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong\u2010Sik","family":"Lee","sequence":"additional","affiliation":[{"name":"Chung\u2010Ang University","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3659-435X","authenticated-orcid":false,"given":"Dawid","family":"Schellingerhout","sequence":"additional","affiliation":[{"name":"University of Texas MD Anderson Cancer Center","place":["Houston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9473-5152","authenticated-orcid":false,"given":"Jinyong","family":"Chung","sequence":"additional","affiliation":[{"name":"National Priority Research Center for Stroke","place":["Goyang, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5179-2480","authenticated-orcid":false,"given":"Hyerin","family":"Oh","sequence":"additional","affiliation":[{"name":"National Priority Research Center for Stroke","place":["Goyang, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010Wuk","family":"Jeong","sequence":"additional","affiliation":[{"name":"Dongguk University Ilsan Hospital","place":["Goyang, Republic of Korea"]},{"name":"National Priority Research Center for Stroke","place":["Goyang, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8194-3462","authenticated-orcid":false,"given":"Ji Sung","family":"Lee","sequence":"additional","affiliation":[{"name":"Asan Medical Center","place":["Seoul, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0051-1997","authenticated-orcid":false,"given":"Hee\u2010Joon","family":"Bae","sequence":"additional","affiliation":[{"name":"Cerebrovascular Center","place":["Seongnam, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9912-6249","authenticated-orcid":false,"given":"Mikyung","family":"Kim","sequence":"additional","affiliation":[{"name":"Dongguk University Ilsan Oriental Hospital","place":["Goyang, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0979-2791","authenticated-orcid":false,"given":"Dong\u2010Jun","family":"Choi","sequence":"additional","affiliation":[{"name":"Dongguk University Ilsan Oriental Hospital","place":["Goyang, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9339-6539","authenticated-orcid":false,"given":"Dong\u2010Eog","family":"Kim","sequence":"additional","affiliation":[{"name":"Dongguk University Ilsan Hospital","place":["Goyang, Republic of Korea"]},{"name":"National Priority Research Center for Stroke","place":["Goyang, Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/heapro\/daw089"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2011.00680.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules181214670"},{"key":"e_1_3_2_5_2","unstructured":"World Health Organization Global Report on Traditional and Complementary Medicine. 2019. 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