{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:19:35Z","timestamp":1790734775760,"version":"4.1.0"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"15","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,8,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Conduction disturbances are frequent complications following transcatheter aortic valve intervention (TAVI), partially driven by inflammation. The anti\u2010inflammatory role of colchicine on these disorders post TAVI has not been studied yet. Therefore, we investigated the association between preoperative colchicine use and conduction disturbances after TAVI.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">We used the TriNetX platform, a data repository of health record data from health care organizations in the United States, to identify patients receiving any colchicine prescription within 3\u2009months before their first TAVI and compared them to propensity score matched patients never exposed to colchicine up to 1\u2009year after the procedure. Primary outcomes included new\u2010onset or worsening atrioventricular or left bundle\u2010branch block (LBBB) and heart block (HB) postoperatively. Outcomes were assessed within 1 and 6\u2009months after TAVI with an E\u2010sensitivity analysis assessing the impact of unmeasured confounders.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              Of 52\u2009860 patients, 705 were on preoperative colchicine. After matching, each group included 702 patients. Colchicine was associated with a statistically significant reduction of new\u2010onset or worsening atrioventricular\/left bundle\u2010branch block and heart block post TAVI at 1\u2009month (relative risk [RR], 0.867 [95% CI, 0.756\u20130.994],\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              =0.041; RR, 0.887 [95% CI, 0.788\u20130.999],\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              =0.047, respectively) but not at 6\u2009months (RR, 0.886 [95% CI, 0.779\u20131.077],\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              =0.064; RR, 0.913 [95% CI, 0.817\u20131.020],\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              =0.109, respectively). The E\u2010value was &gt;1.5 for the statistically significant outcomes.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">Preoperative colchicine was associated with a lower incidence of new\u2010onset or worsening atrioventricular\/left bundle\u2010branch block and heart block after TAVI at 1\u2009month. However, no significant difference was observed at 6\u2009months. Future prospective studies are needed to evaluate the definitive role of colchicine in improving TAVI outcomes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.125.043791","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T11:47:52Z","timestamp":1753789672000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Preoperative Colchicine and Conduction Disturbances After Transcatheter Aortic Valve Implantation: A US Retrospective Cohort Analysis"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2499-5570","authenticated-orcid":false,"given":"Kerollos","family":"Abdelsayed","sequence":"first","affiliation":[{"name":"Minneapolis Heart Institute Foundation","place":["Minneapolis, USA"]},{"name":"Magdi Yacoub Foundation","place":["Aswan, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7787-5508","authenticated-orcid":false,"given":"Basma Ehab","family":"Amer","sequence":"additional","affiliation":[{"name":"Benha University","place":["Benha, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3320-7662","authenticated-orcid":false,"given":"Ahmed","family":"Almahdy Mohamed","sequence":"additional","affiliation":[{"name":"University of Minnesota Twin Cities","place":["Minneapolis, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0397-1422","authenticated-orcid":false,"given":"Michele","family":"Fouad","sequence":"additional","affiliation":[{"name":"Alexandria University","place":["Alexandria, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2687-3880","authenticated-orcid":false,"given":"Ahmed Mazen","family":"Amin","sequence":"additional","affiliation":[{"name":"Mansoura University","place":["Mansoura, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4567-4303","authenticated-orcid":false,"given":"Mahmoud Mahmoud","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"McLaren Health Care","place":["Flint, USA"]},{"name":"Michigan State University","place":["East Lansing, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5846-4620","authenticated-orcid":false,"given":"Sittinun","family":"Thangjui","sequence":"additional","affiliation":[{"name":"West Virginia University","place":["Morgantown, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2919-6196","authenticated-orcid":false,"given":"Basel","family":"Abdelazeem","sequence":"additional","affiliation":[{"name":"West Virginia University","place":["Morgantown, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7872-3757","authenticated-orcid":false,"given":"Sudarshan","family":"Balla","sequence":"additional","affiliation":[{"name":"West Virginia University","place":["Morgantown, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9035-343X","authenticated-orcid":false,"given":"Azeem","family":"Latib","sequence":"additional","affiliation":[{"name":"Montefiore Medical Center, Albert Einstein College of Medicine","place":["Bronx, 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