{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:26:19Z","timestamp":1792416379583,"version":"4.4.0"},"reference-count":87,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"20","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,10,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Little is known about the associations between cardiorespiratory fitness (CRF), grip strength (GS), and their combined effect on multimorbidity. This investigation aimed to identify diseases associated with estimated CRF and GS, evaluate the associations among estimated CRF, GS, and their combination with multimorbidity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">This analysis was based on data from 63\u2009177 individuals who provided valid CRF and GS data in UK Biobank. Phenome\u2010wide association studies identified diseases associated with both CRF and GS, defining multimorbidity. Cox proportional hazard models, logistic regression, and quasi\u2010Poisson mixed effects models were used to investigate the effects of CRF and GS on multimorbidity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">A total of 32 diseases were included to constitute the multimorbidity indicator. During a median follow\u2010up of 11.58\u2009years, at least 2 diseases developed in 21\u2009275 participants. Compared with their lowest tertiles, the highest categories of estimated CRF and GS showed hazard ratios (HR) of 0.77 (95% CI, 0.74\u20130.80) and 0.78 (95% CI, 0.76\u20130.81) for multimorbidity, respectively. The HR for the combination of the highest estimated CRF and GS was 0.62 (95% CI, 0.59\u20130.66). Low estimated CRF and GS were associated with an increased risk of cardiovascular disease, leading to related complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">High estimated CRF and GS were associated with low multimorbidity risk. Maintaining both estimated CRF and GS may be more effective than targeting either alone. Proactive cardiovascular health management is crucial for individuals with low estimated CRF and GS to prevent multisystem multimorbidity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.043830","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T03:16:16Z","timestamp":1761102976000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Estimated Cardiorespiratory Fitness and Grip Strength: Independent and Combined Associations With Multimorbidity Risk and Patterns in a Large\u2010Scale Prospective Cohort Study"],"prefix":"10.1161","volume":"14","author":[{"given":"Xuezhen","family":"Chen","sequence":"first","affiliation":[{"name":"Fujian Medical University","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunfeng","family":"Su","sequence":"additional","affiliation":[{"name":"Quanzhou First Hospital Affiliated to Fujian Medical University","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunting","family":"Chen","sequence":"additional","affiliation":[{"name":"Fujian Medical University","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Fujian Medical University","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[{"name":"Fujian Medical University","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiwen","family":"Liu","sequence":"additional","affiliation":[{"name":"Fujian Medical University","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7546-9124","authenticated-orcid":false,"given":"Jie","family":"Yi","sequence":"additional","affiliation":[{"name":"Fujian Medical University","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinman","family":"Zhuang","sequence":"additional","affiliation":[{"name":"Fujian Medical University","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haomin","family":"Yang","sequence":"additional","affiliation":[{"name":"Fujian Medical University","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9119-9056","authenticated-orcid":false,"given":"Fei","family":"He","sequence":"additional","affiliation":[{"name":"Fujian Medical University","place":["Fuzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","unstructured":"World Health Organization . 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