{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:33:15Z","timestamp":1759969995984,"version":"build-2065373602"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,10,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Percutaneous coronary intervention (PCI) could restore epicardial blood flow through the stent\u2010based angioplasty. However, coronary microcirculatory function also affects clinical outcomes and can be quantified by the angiography\u2010derived index of microcirculatory resistance (angio\u2010IMR). The prognostic significance of periprocedural angio\u2010IMR in patients undergoing elective PCI remains unclear. This study aimed to assess angio\u2010IMR before and after PCI, as well as their association with long\u2010term prognosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">Data from 1768 patients with stable coronary artery disease undergoing elective PCI were analyzed. The primary end point was major adverse cardiac events (MACE) comprising death and nonfatal myocardial infarction.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              The median angio\u2010IMR was 11.3 (interquartile range, 7.7\u201315.0) and 17.0 (interquartile range, 14.1\u201320.4) before and after PCI (\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              &lt;0.001), respectively. During a median follow\u2010up period of 20\u2009months, MACE occurred in 53 patients (3.0%). Periprocedural angio\u2010IMR changes (\u0394angio\u2010IMR) exhibited superior predictive power for MACE compared with post\u2010PCI angio\u2010IMR alone. Specifically, \u0394angio\u2010IMR&gt;10 was independently associated with an increased risk of MACE (adjusted hazard ratio, 2.43 [95% CI, 1.32\u20134.49];\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              =0.004). In comparison with periprocedural myocardial infarction, \u0394angio\u2010IMR&gt;10 could provide additional prognostic value in predicting MACE (area under the curve, 0.681 versus 0.635,\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              &lt;0.05).\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">\u0394angio\u2010IMR was a predictor of MACE in patients with stable coronary artery disease undergoing elective PCI. Incorporating \u0394angio\u2010IMR could enhance the identification of patients at high risk of MACE.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.125.043836","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T07:49:26Z","timestamp":1756799366000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Periprocedural Assessment of Coronary Microcirculatory Function to Predict Clinical Outcomes After Elective Percutaneous Coronary Intervention"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5287-5269","authenticated-orcid":false,"given":"ChenGuang","family":"Li","sequence":"first","affiliation":[{"name":"Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Diseases","place":["Shanghai, China"]},{"name":"National Clinical Research Center for Interventional Medicine","place":["Shanghai, 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