{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T11:09:28Z","timestamp":1784113768692,"version":"3.55.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,2,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Limited data are available comparing clinical outcomes between patients with small and large annuli following transcatheter aortic valve replacement using balloon\u2010expandable valves. This study sought to investigate 5\u2010year clinical outcomes in patients with severe aortic stenosis with a small annulus compared with those with a large annulus following transcatheter aortic valve replacement with newer\u2010generation balloon\u2010expandable valves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      A total of 3182 patients with aortic stenosis treated with balloon\u2010expandable valves were divided into small\u2010annulus (\u2264430\u2009mm\n                      <jats:sup>2<\/jats:sup>\n                      ) and large\u2010annulus (&gt;430\u2009mm\n                      <jats:sup>2<\/jats:sup>\n                      ) groups. A 1:1 propensity\u2010matched analysis was performed to adjust baseline differences. The primary end point was all\u2010cause death at 5\u2010year follow\u2010up. Secondary end points included heart failure hospitalization, bioprosthetic valve failure, and aortic valve reintervention.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Among 533 matched pairs, compared with the large\u2010annulus group, the small\u2010annulus group had higher rates of aortic valve mean gradients \u226520\u2009mm\u2009Hg (14.1% versus 2.9%;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001) and severe prosthesis\u2013patient mismatch (9.8% versus 5.2%;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.019). At 5\u2009years, there were no significant differences in all\u2010cause death (hazard ratio, 0.75 [95% CI, 0.52\u20131.09];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.13). The incidence of heart failure rehospitalization, bioprosthetic valve failure, and aortic valve reintervention were similar between groups. Both groups achieved similar sustained improvements in New York Heart Association functional class and Kansas City Cardiomyopathy Questionnaire\u2013Overall Summary scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Despite higher transvalvular gradients and a greater rate of severe prosthesis\u2013patient mismatch, 5\u2010year clinical outcomes in patients with a small annulus were comparable to those with a large annulus following transcatheter aortic valve replacement using newer\u2010generation balloon\u2010expandable valves.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.043880","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T10:22:33Z","timestamp":1769077353000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Comparing Clinical Outcomes of Patients With a Small Versus Large Annulus After Newer\u2010Generation Balloon\u2010Expandable Transcatheter Aortic Valve Replacement"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2537-4239","authenticated-orcid":false,"given":"Kazuki","family":"Suruga","sequence":"first","affiliation":[{"name":"Smidt Heart Institute","place":["Los Angeles"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7209-3531","authenticated-orcid":false,"given":"Vivek","family":"Patel","sequence":"additional","affiliation":[{"name":"Smidt Heart Institute","place":["Los 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