{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T20:03:00Z","timestamp":1783368180746,"version":"3.54.6"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,1,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Uterine fibroids and atherosclerotic cardiovascular disease (ASCVD) share biological pathways, yet whether risk of ASCVD is different among those with fibroids compared with those without remains unexplored in large US cohorts with longitudinal data. This study assessed the association between uterine fibroids and risk of incident ASCVD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">A US population\u2010based cohort study was done using Optum\u2019s de\u2010identified Clinformatics Data Mart Database (2000\u20132022). Follow\u2010up continued until an ASCVD event, disenrollment, incident fibroid diagnosis in controls, or June 30, 2022. Individuals with fibroids were exact age\u2010matched (1:5) to individuals without fibroids with an annual gynecologic claim. Incident ASCVD, a composite of coronary artery disease, cerebrovascular disease, and peripheral artery disease, was evaluated, including individual events (eg, myocardial infarction and ischemic stroke).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Among 450\u2009177 individuals with fibroids and 2\u2009250\u2009885 controls (mean age: 41\u2009years, SD 6.3), the 1\u2010year and 10\u2010year cumulative incidence (95% CI) of ASCVD was 0.74% (0.71\u20130.77) and 5.42% (5.18\u20135.67) for the fibroid group versus 0.30% (0.29\u20130.31) and 3.00% (2.90\u20133.11) for controls. Adjusted analyses showed an increased ASCVD risk in the fibroid group (1\u2010year risk ratio: 2.47 [95% CI, 2.32\u20132.61]; 1\u2010year risk difference, 0.41% [95% CI, 0.40\u20130.47]; 10\u2010year risk ratio, 1.81 [95% CI, 1.66\u20131.96]; 10\u2010year risk difference, 2.40% [95% CI, 2.07, 2.77]. The increased risk was consistent for all individual components of ASCVD. Results were consistent across race and ethnicity and age subgroup analyses and sensitivity analyses addressing measurement error.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Uterine fibroids are associated with sustained increased ASCVD risks up to 10\u2009years postdiagnosis, supporting targeted ASCVD prevention in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.044014","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T01:35:11Z","timestamp":1765416911000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Association Between Uterine Fibroids and Risk of Atherosclerotic Cardiovascular Disease"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1600-8328","authenticated-orcid":false,"given":"Julia D.","family":"DiTosto","sequence":"first","affiliation":[{"name":"University of Pennsylvania","place":["Philadelphia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3483-5527","authenticated-orcid":false,"given":"Jennifer","family":"Lewey","sequence":"additional","affiliation":[{"name":"University of Pennsylvania Perelman School of Medicine","place":["Philadelphia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarcy","family":"Zee","sequence":"additional","affiliation":[{"name":"University of Pennsylvania","place":["Philadelphia"]},{"name":"Children\u2019s Hospital of Philadelphia Research Institute","place":["Philadelphia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anuja","family":"Dokras","sequence":"additional","affiliation":[{"name":"University of Pennsylvania Perelman School of Medicine","place":["Philadelphia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1892-4194","authenticated-orcid":false,"given":"Kyle R.","family":"Busse","sequence":"additional","affiliation":[{"name":"University of Pennsylvania","place":["Philadelphia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snigdha","family":"Alur\u2010Gupta","sequence":"additional","affiliation":[{"name":"University of Rochester Medical Center","place":["Rochester"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4312-708X","authenticated-orcid":false,"given":"Stefanie","family":"Hinkle","sequence":"additional","affiliation":[{"name":"University of Pennsylvania","place":["Philadelphia"]},{"name":"University of Pennsylvania Perelman School of Medicine","place":["Philadelphia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3757-641X","authenticated-orcid":false,"given":"Enrique F.","family":"Schisterman","sequence":"additional","affiliation":[{"name":"University of Pennsylvania","place":["Philadelphia"]},{"name":"University of Pennsylvania Perelman School of Medicine","place":["Philadelphia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0133-3176","authenticated-orcid":false,"given":"Sunni L.","family":"Mumford","sequence":"additional","affiliation":[{"name":"University of Pennsylvania","place":["Philadelphia"]},{"name":"University of Pennsylvania Perelman School of Medicine","place":["Philadelphia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen C.","family":"Caniglia","sequence":"additional","affiliation":[{"name":"University of Pennsylvania","place":["Philadelphia"]},{"name":"University of Pennsylvania Perelman School of Medicine","place":["Philadelphia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0000000000004401"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.99"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.08.008"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31820780e3"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2022.12.008"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/ogx.0000000000000718"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1530\/rep-21-0087"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-6175.2005.04384.x"},{"key":"e_1_3_1_10_2","first-page":"175","article-title":"Human atherosclerotic plaque cells and leiomyoma cells. 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