{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T07:13:09Z","timestamp":1775805189796,"version":"3.50.1"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,2,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Chronic kidney disease (CKD) is prevalent in patients undergoing percutaneous coronary intervention for chronic total occlusion and is associated with worse outcomes due to impaired renal function. Understanding the outcomes and predictors of adverse events in this population is crucial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      A retrospective observational study was conducted on patients undergoing chronic total occlusion percutaneous coronary intervention at Houston Methodist DeBakey Heart and Vascular Center (2018\u20132023). Patients were categorized on the basis of kidney function: CKD (estimated glomerular filtration rate &lt;60\u2009mL\/min per 1.73\u2009m\n                      <jats:sup>2<\/jats:sup>\n                      ) and non\u2010CKD. The primary end point was procedural success. Secondary end points included 1\u2010year all\u2010cause death; clinically driven target\u2010lesion revascularization at 1 year; target\u2010lesion failure, defined as the composite of heart failure hospitalization, stroke, target\u2010lesion revascularization, and myocardial infarction at 1 year; in\u2010stent restenosis at 1 year, and in\u2010hospital complications.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      A total of 492 patients were included, with 176 (35.8%) diagnosed with CKD. Patients with CKD were older and had a higher comorbidity burden. Patients with CKD had more complex disease, with higher rates of multivessel disease and graft vessel stenosis. Procedural success rates were high and similar between the groups (83.0% versus 83.4%). While 1\u2010year all\u2010cause death was comparable, patients with CKD exhibited higher rates of target lesion revascularization (hazard ratio, 2.41 [95% CI, 1.53\u20133.78];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). Procedural complexity was not found as an independent predictor of death or target lesion revascularization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Although chronic total occlusion percutaneous coronary intervention is associated with higher postprocedural outcomes in patients with CKD, procedural success was comparable between the groups. Further studies are needed to refine postprocedural management strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.044022","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T11:02:15Z","timestamp":1770807735000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Chronic Kidney Disease on Outcomes of Percutaneous Coronary Interventions for Chronic Total Occlusions: Insights From Houston Methodist Chronic Total Occlusion Registry"],"prefix":"10.1161","volume":"15","author":[{"given":"Chloe","family":"Kharsa","sequence":"first","affiliation":[{"name":"Houston Methodist DeBakey Heart and Vascular Center","place":["Houston, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0383-6471","authenticated-orcid":false,"given":"Gal","family":"Sella","sequence":"additional","affiliation":[{"name":"Houston Methodist DeBakey Heart and Vascular Center","place":["Houston, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1763-9340","authenticated-orcid":false,"given":"Yasser M.","family":"Sammour","sequence":"additional","affiliation":[{"name":"Houston Methodist DeBakey Heart and Vascular Center","place":["Houston, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1953-5956","authenticated-orcid":false,"given":"Rody G.","family":"Bou Chaaya","sequence":"additional","affiliation":[{"name":"Houston Methodist DeBakey Heart and Vascular Center","place":["Houston, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5508-5107","authenticated-orcid":false,"given":"Mangesh","family":"Kritya","sequence":"additional","affiliation":[{"name":"Houston Methodist DeBakey Heart and Vascular Center","place":["Houston, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9229-0290","authenticated-orcid":false,"given":"Jerrin","family":"Philip","sequence":"additional","affiliation":[{"name":"Houston Methodist DeBakey Heart and Vascular Center","place":["Houston, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3907-4448","authenticated-orcid":false,"given":"Muhammad Haisum","family":"Maqsood","sequence":"additional","affiliation":[{"name":"Houston Methodist DeBakey Heart and Vascular Center","place":["Houston, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4334-8133","authenticated-orcid":false,"given":"Neal S.","family":"Kleiman","sequence":"additional","affiliation":[{"name":"Houston Methodist DeBakey Heart and Vascular Center","place":["Houston, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8600-6352","authenticated-orcid":false,"given":"Alpesh R.","family":"Shah","sequence":"additional","affiliation":[{"name":"Houston Methodist DeBakey Heart and Vascular Center","place":["Houston, USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","unstructured":"Fefer P Knudtson ML Cheema AN Galbraith PD Osherov AB Yalonetsky S Gannot S Samuel M Weisbrod M Bierstone D et\u00a0al. 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