{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:03:41Z","timestamp":1789715021745,"version":"4.0.1"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,5,19]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The use of angiogram\u2010based fractional flow reserve technologies in routine clinical practice is increasing steadily. Available data suggest that it is associated with comparable clinical outcomes compared with wire\u2010based fractional flow reserve (FFR), but evidence is still limited, especially in patients with acute coronary syndromes (ACSs). The aim of this study was to examine the real\u2010world clinical outcomes of an angiogram based fractional flow reserve technology (FFRangio; CathWorks, Kfar\u2010Saba, Israel) to guide treatment for coronary artery disease in patients presenting with acute versus chronic coronary syndromes (CCSs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">This is a retrospective, observational study. Our cohort included consecutive patients undergoing coronary angiography in 7 centers (Japan, 6; Israel, 1), whose treatment was guided by FFRangio between January 2021 and December 2023. The primary end point was 2\u2010year cumulative incidence of major adverse cardiac events, stratified by presentation (ACS\/CCS) and treatment strategy (revascularization\/deferral).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Overall, 2245 patients (ACS, 756; CCS, 1489) were included. Patients with ACS were younger and more likely to be diabetic. At 2\u2009years, ACS presentation resulted in higher risk of major adverse cardiac events (9.8% versus 5.6%; HR, 1.80;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). Stratified by presentation and treatment, deferred patients had similar risk of major adverse cardiac events (ACS, 5.4%; CCS, 4.7%; HR, 1.08;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.672) for treated patients, ACS presentation associated with increased risk for major adverse cardiac events (11.7% versus 7.3%; HR, 1.64;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In a real\u2010world setting, FFRangio\u2010guided treatment yields 2\u2010year outcomes comparable with current data for wire\u2010based fractional flow reserve for both patients with ACS and patients with CCS. ACS presentation is associated with increased risk for major adverse cardiac events in patients undergoing FFRangio\u2010guided revascularization but not deferral. These results demonstrate the clinical utility of FFRangio\u2010guided treatment across the spectrum of coronary artery disease presentation excluding ST\u2010segment\u2013elevation myocardial infarction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      URL:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT05648396?term=FFRangio%20\">https:\/\/clinicaltrials.gov\/study\/NCT05648396?term=FFRangio%20&amp;viewType=Card&amp;rank=3<\/jats:ext-link>\n                      ; Unique Identifier: NCT05648396.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.044105","type":"journal-article","created":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T09:09:29Z","timestamp":1778058569000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010World Outcomes of FFRangio\u2010Guided Treatment for Coronary Artery Disease in Acute Versus Chronic Coronary Syndromes"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2110-0484","authenticated-orcid":false,"given":"Guy","family":"Witberg","sequence":"first","affiliation":[{"name":"Rabin Medical Centre","place":["Petach\u2010Tikva, Israel"]},{"name":"Tel\u2010Aviv University","place":["Tel\u2010Aviv, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6282-0990","authenticated-orcid":false,"given":"Yuetsu","family":"Kikuta","sequence":"additional","affiliation":[{"name":"Fukuyama Cardiovascular 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Contemporary nationwide trends in dual utilization of intravascular imaging and invasive physiology in percutaneous coronary intervention among older adults. 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