{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:36:21Z","timestamp":1790609781324,"version":"4.1.0"},"reference-count":71,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,1,20]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Recent data report individuals with colorectal cancer (CRC) to be 2 to 4 times more likely to develop cardiovascular disease (CVD), while established CVD risk factors are linked with an elevated risk of CRC. This study aimed to evaluate national trends in combined CRC and CVD mortality in the United States and assess variations by demographic and geographic characteristics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Combined mortality\u2010related deaths in the United States were extracted using the Centers for Disease Control and Prevention Wide\u2010Ranging Online Data for Epidemiologic Research (CDC WONDER). The Multiple Cause\u2010of\u2010Death Public Use record death certificates were studied to identify records in which both CRC and CVD were mentioned as either contributing or underlying causes of death on nationwide death certificates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Between 1999 and 2019, a total of 1,303,016 CRC\u2010related deaths occurred in individuals aged \u226525\u2009years, of which 394,871 (31.8%) deaths also noted CVD. The overall CRC+CVD\u2010related age\u2010adjusted mortality rate per 100\u2009000 declined from 12.06 in 1999 to 6.69 in 2019. The age\u2010adjusted mortality rates were higher in men (11.1) versus women (7.2). Among young adults aged 35 to 44\u2009years, the crude mortality rates increased annually by 1.8% from 1999 to 2019. The age\u2010adjusted mortality rates were highest for non\u2010Hispanic Black or African American individuals and lowest for non\u2010Hispanic Asian or Pacific Island people (12.22 versus 6.19). The rates were higher in nonmetropolitan (9.77) than metropolitan (8.58) counties and varied by region, being highest in the Northeast (10.6), followed by the West (9.0), Midwest (8.4), and South (7.9).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Nearly one\u2010third of CRC\u2010related deaths also involved CVD. Although combined\u00a0mortality has declined overall, it remains disproportionately high among men, Black or African American individuals, and rural populations. Notably, mortality is increasing among adults aged 35 to 44 years, highlighting persistent disparities and the urgent need for integrated cardiometabolic prevention strategies in patients with cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.044126","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T11:42:02Z","timestamp":1768390922000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Two\u2010Decade Trends in Colorectal Cancer and Cardiovascular Disease\u2013Related Mortality in the US Adult Population, 1999 to 2019"],"prefix":"10.1161","volume":"15","author":[{"given":"Farah","family":"Yasmin","sequence":"first","affiliation":[{"name":"Yale School of Medicine","place":["New Haven, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6705-2030","authenticated-orcid":false,"given":"Muhammad S.","family":"Asghar","sequence":"additional","affiliation":[{"name":"Advent Health","place":["Sebring, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0447-7186","authenticated-orcid":false,"given":"Taha","family":"Mansoor","sequence":"additional","affiliation":[{"name":"Western Michigan University","place":["Kalamazoo, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farwa","family":"Zaidi","sequence":"additional","affiliation":[{"name":"Dow Medical College","place":["Karachi, Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5145-8626","authenticated-orcid":false,"given":"Ali B. 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