{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T04:01:51Z","timestamp":1783828911737,"version":"3.55.0"},"reference-count":55,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,11,4]]},"abstract":"<jats:p xml:lang=\"en\">Ventricular fibrillation (VF) is common among patients with out\u2010of\u2010hospital cardiac arrest. Cardiac arrest with VF has a more favorable prognosis than those with other rhythms, but about 25% of patients with VF are still fibrillating after 3 attempts at defibrillation. Use of 2 defibrillators close together in time, \u201cdouble sequential external defibrillation\u201d (DSED), has been proposed to treat patients who remain in VF. The DOSE VF (Defibrillation Strategies for Refractory Ventricular Fibrillation) trial enrolled patients with out\u2010of\u2010hospital cardiac arrest with refractory VF to compare DSED versus vector change defibrillation versus standard defibrillation. This trial reported a significant increase in survival with DSED and vector change. DSED was also associated with a significant increase in favorable neurologic outcome. No manual or automated defibrillator is approved for use for DSED. Clinicians can choose to use defibrillators to apply DSED off label at their discretion. But in the absence of recommendations from evidence\u2010based guidelines, Food and Drug Administration, manufacturers, and clinicians face uncertainty about the effectiveness of DSED, its potential disruption of cardiopulmonary resuscitation interruption or use of other effective therapies, as well as potential adverse effects on patients to whom it is applied, and damage to the defibrillator. A collaborative, precompetitive thinktank including academic clinicians and researchers, regulators, and device manufacturers participated in a daylong meeting coconvened by the American Heart Association, the Cardiac Safety Research Consortium and the Food and Drug Administration. We summarize the discussion that sought to advance the understanding of the benefits and risks associated with DSED in patients who remain in VF.<\/jats:p>","DOI":"10.1161\/jaha.125.044130","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:17:55Z","timestamp":1762175875000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Scientific Priorities Related to the Use of Double Sequential External Defibrillation in Patients With Refractory Cardiac Arrest: Report From a Multistakeholder Thinktank"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2670-0000","authenticated-orcid":false,"given":"Graham","family":"Nichol","sequence":"first","affiliation":[{"name":"University of Washington","place":["Seattle, 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