{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T17:29:11Z","timestamp":1792949351476,"version":"4.5.0"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,3,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Tricuspid regurgitation (TR) is a common valvular disorder that can affect patients\u2019 quality of life and survival. The impact of TR etiology on overall survival and the associated risk factors in each subgroup are not well studied.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Multisite, retrospective study evaluating survival based on TR etiology using Kaplan\u2013Meier and Cox regression models. Stepwise approach was used to define TR etiology (\u2265moderate): primary (PTR; presence of a primary valvular pathology), lead associated (LTR; lead interfering with closure), and secondary TR (STR) in the setting of left\u2010sided valvular disease, left ventricular disease, other causes of pulmonary hypertension, right ventricular disease, and atrial secondary TR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      A total of 12\u2009899 patients were included (3% PTR, 90% STR, 7% LTR). The mean age was 68\u00b114, 73\u00b113, and 71\u00b113\u2009years, respectively (44%\u201355% female patients). Adjusting for age, sex, and TR severity, patients with PTR had better overall survival (PTR: reference; STR hazard ratio [HR], 1.4 [1.2\u20131.6], LTR HR, 1.5 [1.1\u20131.7]). On multivariable Cox regression, the Tricuspid Regurgitation Impact on Outcomes score was associated with mortality across all groups (\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.05 for all). In addition, other risk factors associated with worse outcomes included pulmonary hypertension and \u2265moderate right ventricular enlargement in PTR; left\u2010sided valvular disease, pulmonary hypertension, and \u2265moderate right ventricular dysfunction in STR; and left ventricular disease and \u2265moderate right ventricular dysfunction in LTR.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Patients with PTR have better survival than STR and LTR. Tricuspid Regurgitation Impact on Outcomes score was associated with mortality across etiologies, whereas other risk factors are etiology specific. Improved risk profiling may enhance patient selection, treatment decisions, and outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.044323","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T10:19:11Z","timestamp":1772187551000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Survival and Risk Profile of Patients With Significant Tricuspid Regurgitation by Etiology"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7632-666X","authenticated-orcid":false,"given":"Mohamad S.","family":"Alabdaljabar","sequence":"first","affiliation":[{"name":"Mayo Clinic","place":["Rochester, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9868-4011","authenticated-orcid":false,"given":"Andrea O.","family":"Ciobanu","sequence":"additional","affiliation":[{"name":"Mayo Clinic","place":["Rochester, USA"]},{"name":"\"Carol Davila\" University of Medicine and Pharmacy","place":["Bucharest, Romania"]},{"name":"University and Emergency Hospital","place":["Bucharest, Romania"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6210-7669","authenticated-orcid":false,"given":"Jwan A.","family":"Naser","sequence":"additional","affiliation":[{"name":"Mayo Clinic","place":["Rochester, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilal O.","family":"Kucuk","sequence":"additional","affiliation":[{"name":"Mayo Clinic","place":["Rochester, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5120-5581","authenticated-orcid":false,"given":"Francisco","family":"Alexandrino","sequence":"additional","affiliation":[{"name":"Mayo Clinic","place":["Rochester, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6095-5579","authenticated-orcid":false,"given":"Vuyisile T.","family":"Nkomo","sequence":"additional","affiliation":[{"name":"Mayo Clinic","place":["Rochester, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garvan C.","family":"Kane","sequence":"additional","affiliation":[{"name":"Mayo Clinic","place":["Rochester, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6800-3521","authenticated-orcid":false,"given":"Patricia A.","family":"Pellikka","sequence":"additional","affiliation":[{"name":"Mayo Clinic","place":["Rochester, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5256-3150","authenticated-orcid":false,"given":"Sorin V.","family":"Pislaru","sequence":"additional","affiliation":[{"name":"Mayo Clinic","place":["Rochester, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7580-1314","authenticated-orcid":false,"given":"Vidhu","family":"Anand","sequence":"additional","affiliation":[{"name":"Mayo Clinic","place":["Rochester, USA"]},{"name":"Mayo Clinic Health System, Northwest Wisconsin","place":["Eau Claire, 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