{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:55:19Z","timestamp":1789541719377,"version":"build-2803163510"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,11,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Vasoactives are the predominant first line of therapy for management of cardiogenic shock (CS). Contemporary practice patterns regarding vasoactive agent selection in CS have not been well characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">The American Heart Association (AHA) CS Registry captures consecutive CS admissions across participating hospitals in the United States. Admissions treated with vasoactive agents within 6\u2009hours of CS onset were included. Agents were categorized as inopressors (norepinephrine, epinephrine, dopamine), inodilators (dobutamine, milrinone), and pure vasopressors (vasopressin, phenylephrine).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">From 2022 to 2024, among 6847 CS admissions across 84 sites, 3387 (49.5%) were treated with a single vasoactive agent and 3460 (50.5%) were treated with \u22652 agents. Inopressors were used most commonly (73.7% of CS cases), with inodilators and pure vasopressors used in 48.3% and 27.5% of cases respectively. Norepinephrine was used most frequently (64.7%), followed by dobutamine (31.6%) and epinephrine (28.9%). Pure vasopressor use consisted primarily of vasopressin (83.5% of use). Use patterns differed by CS etiology with greater inopressor use in acute myocardial infarction\u2010CS and greater inodilator use in acute\u2010on\u2010chronic heart failure\u2010CS. Use of inopressors and pure vasopressors was greater and inodilator use lower in those with cardiac arrest, supported by mechanical circulatory support, or at higher Society of Cardiovascular Angiography and Interventions shock stage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In a broad population with CS in contemporary practice, inopressors are the most commonly used vasoactive category, with norepinephrine being the most frequently used agent. Several factors including CS etiology and severity are associated with differential practice patterns for vasoactive selection. These data depict the contemporary landscape and may help inform future evidence generation around optimal vasoactive selection for patients with CS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.044373","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:47:56Z","timestamp":1761648476000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Contemporary Practice Patterns of Vasoactive Use in Cardiogenic Shock in the American Heart Association Cardiogenic Shock Registry"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4637-4361","authenticated-orcid":false,"given":"Siddharth M.","family":"Patel","sequence":"first","affiliation":[{"name":"Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0366-5492","authenticated-orcid":false,"given":"David D.","family":"Berg","sequence":"additional","affiliation":[{"name":"Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5559-8172","authenticated-orcid":false,"given":"Erin A.","family":"Bohula","sequence":"additional","affiliation":[{"name":"Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2128-6752","authenticated-orcid":false,"given":"Michael G.","family":"Palazzolo","sequence":"additional","affiliation":[{"name":"Harvard Medical School","place":["Boston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3016-1150","authenticated-orcid":false,"given":"Wayne B.","family":"Batchelor","sequence":"additional","affiliation":[{"name":"Inova Heart and Vascular Institute","place":["Falls Church, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1223-327X","authenticated-orcid":false,"given":"Stavros G.","family":"Drakos","sequence":"additional","affiliation":[{"name":"University of Utah Health and School of Medicine","place":["Salt Lake City, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arman","family":"Kilic","sequence":"additional","affiliation":[{"name":"Medical University of South Carolina","place":["Charleston, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1421-7123","authenticated-orcid":false,"given":"Robert L.","family":"Kormos","sequence":"additional","affiliation":[{"name":"Abbott Laboratories","place":["Austin, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7524-5174","authenticated-orcid":false,"given":"Marc D.","family":"Samsky","sequence":"additional","affiliation":[{"name":"Yale School of Medicine","place":["New Haven, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3010-0112","authenticated-orcid":false,"given":"Mariell","family":"Jessup","sequence":"additional","affiliation":[{"name":"American Heart Association","place":["Dallas, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell W.","family":"Krucoff","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine","place":["Durham, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9589-5382","authenticated-orcid":false,"given":"David A.","family":"Morrow","sequence":"additional","affiliation":[{"name":"Harvard Medical 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