{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T01:48:27Z","timestamp":1792460907982,"version":"4.5.0"},"reference-count":51,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,10,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n            <jats:title>Background<\/jats:title>\n            <jats:p xml:lang=\"en\">Mavacamten is commercially approved for use in symptomatic patients with obstructive hypertrophic cardiomyopathy. This study evaluated its real\u2010world impact on symptoms, echocardiographic changes, and the need for septal reduction therapy in patients with obstructive hypertrophic cardiomyopathy treated at a multihospital referral center.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Methods<\/jats:title>\n            <jats:p xml:lang=\"en\">We included 244 patients with obstructive hypertrophic cardiomyopathy (mean age, 64\u2009years; 57% women, 21% with atrial fibrillation, 51% New York Heart Association class III, 82% on \u03b2\u2010blockers) treated with mavacamten for \u22653\u2009months (171 for \u226512\u2009months). Serial clinical and echocardiographic assessments were performed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Results<\/jats:title>\n            <jats:p xml:lang=\"en\">\n              New York Heart Association class distribution improved over time: at 3\u2009months 21% class I, 61% class II, and 18% class III; at 12\u2009months 36% class I, 57% class II, and 8% class III. After a mean of 1.02\u2009years, significant improvements were observed in resting and post\u2010Valsalva left ventricular outflow tract gradients (\u221231\u00b133 and \u221257\u00b146\u2009mm\u2009Hg), interventricular septal thickness (\u22121.7\u00b14\u2009mm), left ventricular mass index (\u22129.5\u00b132\u2009g\/m\n              <jats:sup>2<\/jats:sup>\n              ), left atrial volume index (\u221212\u00b113\u2009mL\/m\n              <jats:sup>2<\/jats:sup>\n              ), E\/e\u2032 (\u22125.5\u00b16.4), left ventricular global longitudinal strain (1.04%\u00b13.1%), and various left atrial and right ventricular strain measures (all\n              <jats:italic toggle=\"no\">P<\/jats:italic>\n              &lt;0.05). Temporary interruption occurred in 8 patients (3.2%), and 3 (1.2%) discontinued mavacamten permanently. There were 2 noncardiac deaths, 7 heart failure admissions, 14 cases of new\u2010onset atrial fibrillation, and 1 patient required septal reduction therapy. At the last visit, most patients were on 5\u2009mg (49%) or 10\u2009mg (26%) mavacamten.\n            <\/jats:p>\n          <\/jats:sec>\n          <jats:sec xml:lang=\"en\">\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p xml:lang=\"en\">In this real\u2010world cohort, mavacamten treatment was associated with sustained symptomatic and echocardiographic improvements, suggesting a favorable disease\u2010modifying impact with minimal need for septal reduction therapy.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1161\/jaha.125.044537","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T13:30:56Z","timestamp":1756733456000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Real\u2010World Observations in Patients With Obstructive Hypertrophic Cardiomyopathy Treated With Mavacamten: Evidence of Favorable Disease Modification"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0010-9797","authenticated-orcid":false,"given":"Milind Y.","family":"Desai","sequence":"first","affiliation":[{"name":"Heart Vascular and Thoracic Institute, Cleveland Clinic","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8619-3400","authenticated-orcid":false,"given":"Andrew","family":"Gaballa","sequence":"additional","affiliation":[{"name":"Heart Vascular and Thoracic Institute, Cleveland Clinic","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8534-6760","authenticated-orcid":false,"given":"Yuichiro","family":"Okushi","sequence":"additional","affiliation":[{"name":"Heart Vascular and Thoracic Institute, Cleveland Clinic","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8658-8656","authenticated-orcid":false,"given":"Mohammed","family":"Abusafia","sequence":"additional","affiliation":[{"name":"Heart Vascular and Thoracic Institute, Cleveland Clinic","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6175-4775","authenticated-orcid":false,"given":"Shada","family":"Jadam","sequence":"additional","affiliation":[{"name":"Heart Vascular and Thoracic Institute, Cleveland Clinic","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katy","family":"Rutkowski","sequence":"additional","affiliation":[{"name":"Heart Vascular and Thoracic Institute, Cleveland Clinic","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7175-6582","authenticated-orcid":false,"given":"Susan","family":"Ospina","sequence":"additional","affiliation":[{"name":"Heart Vascular and Thoracic Institute, Cleveland Clinic","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanaa","family":"Sultana","sequence":"additional","affiliation":[{"name":"Heart Vascular and Thoracic Institute, Cleveland Clinic","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maran","family":"Thamilarasan","sequence":"additional","affiliation":[{"name":"Heart Vascular and Thoracic Institute, Cleveland Clinic","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Asher","sequence":"additional","affiliation":[{"name":"Heart Vascular and Thoracic Institute, Cleveland Clinic","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5692-2299","authenticated-orcid":false,"given":"Zoran B.","family":"Popovic","sequence":"additional","affiliation":[{"name":"Heart Vascular and Thoracic Institute, Cleveland Clinic","place":["Cleveland, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2985-7468","authenticated-orcid":false,"given":"Bo","family":"Xu","sequence":"additional","affiliation":[{"name":"Heart Vascular and Thoracic Institute, Cleveland Clinic","place":["Cleveland, 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