{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T07:56:46Z","timestamp":1794124606852,"version":"4.8.0"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"21","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,11,4]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Patients with coronary artery disease or heart failure (HF) face heightened COVID\u201019 and cardiovascular risk, yet the long\u2010term cardiac effects of COVID\u201019 vaccination in this population remain uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We performed a retrospective, propensity\u2010matched cohort study using the TriNetX US Collaborative Network (December 2020\u2013December 2022). Adults with coronary artery disease or HF were matched 1:1, creating 74\u2009236 vaccinated and 74\u2009236 calendar\u2010aligned unvaccinated patients. Outcomes included mortality, acute myocardial infarction, stroke, HF hospitalization, deep vein thrombosis\/pulmonary embolism, atrial fibrillation hospitalization, myocarditis, pericarditis, percutaneous coronary intervention, and coronary artery bypass grafting at 1\u2010year and 2\u2010year follow\u2010ups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Vaccination was associated with a dose\u2010dependent reduction in all\u2010cause mortality. Landmark hazard ratios (HRs) remained favorable, 0.92 (95% CI, 0.89\u20130.95), 0.99 (95% CI, 0.96\u20131.02), and 0.72 (95% CI, 0.70\u20130.74), confirming robustness across time periods. Vaccination was also associated with fewer HF hospitalizations (2\u2010year HR, 0.90 [95% CI, 0.87\u20130.94]) and lower revascularization rates (percutaneous coronary intervention HR, 0.87; coronary artery bypass grafting HR, 0.80), while showing no significant association with acute myocardial infarction, stroke, or venous thromboembolism. Although the study was underpowered to definitively assess rare safety events, a small increase in myocarditis was observed (2\u2010year HR, 1.36), representing a potential safety signal that warrants further investigation; pericarditis was not significantly elevated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">COVID\u201019 vaccination was associated with a graded reduction in mortality that persisted after landmark adjustment, as well as lower rates of HF admissions and revascularizations. Findings support the use of complete vaccination, including boosters, as part of secondary prevention, pending confirmation in prospective studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.044546","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:51:26Z","timestamp":1761648686000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["COVID\u201019 Vaccination and Cardiovascular Outcomes in Older Adults With Coronary Artery Disease and Heart Failure: Insights From a Large Propensity\u2010Matched Cohort\u00a0Study"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4501-1005","authenticated-orcid":false,"given":"Usman Ali","family":"Akbar","sequence":"first","affiliation":[{"name":"WVU Medicine \u2013 Camden Clark Medical Center","place":["Parkersburg, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0457-5851","authenticated-orcid":false,"given":"Harshith","family":"Thyagaturu","sequence":"additional","affiliation":[{"name":"West Virginia University","place":["Morgantown, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6836-4490","authenticated-orcid":false,"given":"Amro","family":"Taha","sequence":"additional","affiliation":[{"name":"West Virginia University","place":["Morgantown, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalitsiri","family":"Atti","sequence":"additional","affiliation":[{"name":"Sparrow Hospital, Michigan State University","place":["Lansing, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2003-922X","authenticated-orcid":false,"given":"Allahdad","family":"Khan","sequence":"additional","affiliation":[{"name":"Nishtar Medical University","place":["Multan, Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer","family":"Raina","sequence":"additional","affiliation":[{"name":"Stanford University","place":["Stanford, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7872-3757","authenticated-orcid":false,"given":"Sudarshan","family":"Balla","sequence":"additional","affiliation":[{"name":"West Virginia University","place":["Morgantown, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","volume-title":"Cardiovascular Diseases (CVDs)","author":"World Health Organization","year":"2021","unstructured":"World Health Organization . Cardiovascular Diseases (CVDs). World Health Organization website; 2021. Accessed July 19, 2025. https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/cardiovascular\u2010diseases\u2010(cvds)"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartjsupp\/suac123"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.057042"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-021-00620-6"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2003.10.018"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-022-01748-8"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.13946"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.017756"},{"key":"e_1_3_1_10_2","unstructured":"TriNetX . TriNetX Platform. 2025. Accessed July 19 2025. https:\/\/live.trinetx.com."},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001885"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7050e2"},{"key":"e_1_3_1_13_2","unstructured":"Centers for Disease Control and Prevention . Moderna COVID\u201019 Vaccine: Preparation and Administration Summary. 2021. Accessed July 19 2025. https:\/\/www.cdc.gov\/vaccines\/covid\u201019\/info\u2010by\u2010product\/moderna\/downloads\/storage\u2010prep.pdf."},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2022.05.008"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae639"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46497-0"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-024-02173-5"},{"key":"e_1_3_1_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.750887"},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.240876"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.12992"},{"key":"e_1_3_1_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-024-00825-z"},{"key":"e_1_3_1_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-022-00876-6"},{"key":"e_1_3_1_23_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.124.035827"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d1250"},{"key":"e_1_3_1_25_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11061584"},{"key":"e_1_3_1_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01630-0"},{"key":"e_1_3_1_27_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.24110"},{"key":"e_1_3_1_28_2","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.123.032426"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/agm2.12149"},{"key":"e_1_3_1_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/s44325-024-00011-z"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrtlng.2023.02.003"},{"key":"e_1_3_1_32_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2022-071594"},{"key":"e_1_3_1_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-61641-y"},{"key":"e_1_3_1_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.2356"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.125.044546","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:22:40Z","timestamp":1780485760000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.125.044546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,4]]},"references-count":33,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2025,11,4]]}},"alternative-id":["10.1161\/JAHA.125.044546"],"URL":"https:\/\/doi.org\/10.1161\/jaha.125.044546","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,4]]},"assertion":[{"value":"2025-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e044546"}}