{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:45:31Z","timestamp":1782992731732,"version":"3.54.5"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,3,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Pulmonary hypertension (PH) and sensitization adversely affect heart transplant outcomes. Although left ventricular assist devices may reduce PH, they can increase sensitization. We examined the impact of sensitization on heart transplant outcomes in left ventricular assist device\u2010bridged patients and whether precapillary PH modifies this effect.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Adults bridged to heart transplant with an left ventricular assist device between 2005 and 2020 were identified from the United Network for Organ Sharing database. Patients with available panel\u2010reactive antibody (PRA) and hemodynamic data were included. Associations between PRA and survival and treated rejection were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Among 2469 patients, 1053 had precapillary PH (pulmonary vascular resistance [PVR] &gt;2 Wood units [WU]) and 1416 had PVR \u22642 WU. Elevated PRA (&gt;10%) occurred in 566 patients (24.8% with PVR &gt;2 WU; 21.5% with PVR \u22642 WU). Overall, PRA &gt;10% was associated with increased mortality (adjusted hazard ratio [aHR], 1.28 [95% CI, 1.04\u20131.58],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.022), driven by patients with PVR &gt;2 WU (aHR, 1.82 [95% CI, 1.34\u20132.50],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001), with no association in those with PVR \u22642 WU (aHR, 0.99 [95% CI, 0.47\u20131.32],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.92). PRA &gt;10% was also associated with treated rejection overall (adjusted odds ratio [aOR], 1.41 [95% CI, 1.09\u20131.82],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.008), confined to the PVR &gt;2 WU group (aOR, 1.87 [95% CI, 1.26\u20132.76],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.002) and absent in the PVR \u22642 WU group (aOR, 1.13 [95% CI, 0.80\u20131.59],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.49).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Elevated PRA predicts worse outcomes in LVAD\u2010bridged transplant recepients with precapillary PH, but not in those without precapillary PH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.044572","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T12:40:39Z","timestamp":1772628039000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Interplay of Pulmonary Hypertension and the Effects of Panel\u2010Reactive Antibodies on Outcomes of Heart Transplant Recipients Bridged With Left Ventricular Assist Device"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8241-4324","authenticated-orcid":false,"given":"Fouad","family":"Khalil","sequence":"first","affiliation":[{"name":"University of Nebraska Medical Center","place":["Omaha, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0258-7402","authenticated-orcid":false,"given":"Rabea","family":"Asleh","sequence":"additional","affiliation":[{"name":"Hebrew University of Jerusalem","place":["Jerusalem, Israel"]},{"name":"Mayo Clinic","place":["Rochester, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Mawer","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center","place":["Omaha, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn","family":"Kim","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center","place":["Omaha, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8964-5582","authenticated-orcid":false,"given":"Ohad","family":"Regev","sequence":"additional","affiliation":[{"name":"Ben Gurion University of the Negev","place":["Beersheva, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5740-9670","authenticated-orcid":false,"given":"Alexandros","family":"Briasoulis","sequence":"additional","affiliation":[{"name":"University of Iowa Hospitals and Clinics","place":["Iowa City, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1537-5668","authenticated-orcid":false,"given":"Hilmi","family":"Alnsasra","sequence":"additional","affiliation":[{"name":"Mayo Clinic","place":["Rochester, USA"]},{"name":"Ben Gurion University of the Negev","place":["Beersheva, Israel"]},{"name":"Soroka University Medical Center","place":["Beersheva, Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12684"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2007.05.095"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.98.8.786"},{"key":"e_1_3_2_5_2","first-page":"Ii294","article-title":"Pretransplant panel reactive\u2010antibody screens. 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Influence of panel\u2010reactive antibody and lymphocytotoxic crossmatch on survival after heart transplantation. 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