{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:03:27Z","timestamp":1789715007222,"version":"4.0.1"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,4,7]]},"abstract":"\n Background<\/jats:title>\n Advanced age may influence the benefits derived from transcatheter edge\u2010to\u2010edge repair for primary mitral regurgitation (MR). We explored the impact of age on clinical, echocardiographic, functional, and patient\u2010reported outcomes after contemporary mitral transcatheter edge\u2010to\u2010edge repair.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Patients with primary MR were identified from a pooled, patient\u2010level analysis of the EXPAND and EXPAND G4 studies. Key outcomes included 30\u2010day and 1\u2010year major adverse events, MR severity, New York Heart Association class, Kansas City Cardiomyopathy Questionnaire \u2013 Overall Summary score, and mortality.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 854 patients were included. The oldest quartile ranged in age from 86 to 99\u2009years, while the younger quartiles ranged from 21 to 85\u2009years. The 30\u2010day major adverse events rate was not different in the oldest compared with the younger quartiles (5.7% versus 4.3%,\n P<\/jats:italic>\n =0.46). At 1\u2009year, MR \u22641+ was present in 81% of the oldest versus 88% of the younger patients (\n P<\/jats:italic>\n =0.08). LV end\u2010diastolic volumes improved to similar extent (\u221212.0\u00b128.8\u2009mL,\n P<\/jats:italic>\n =0.003 and \u221214.1\u00b131.5\u2009mL,\n P<\/jats:italic>\n <0.0001,\n P<\/jats:italic>\n =0.34 across groups). Functional status and Kansas City Cardiomyopathy Questionnaire \u2013 Overall Score improved significantly across age groups, without differences according to age. Adjusted 1\u2010year mortality was higher in the oldest compared with the younger quartiles (adjusted hazard ratio 1.74 [95% CI, 1.02\u20132.98],\n P<\/jats:italic>\n =0.04).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Although 1\u2010year mortality was higher among the very elderly, mitral transcatheter edge\u2010to\u2010edge repair using next\u2010generation devices was associated with low complication rates and substantial improvements in ventricular remodeling, functional status, and quality of life across age groups. These findings support the use of mitral transcatheter edge\u2010to\u2010edge repair in appropriately selected elderly patients and suggest that age alone should not be a barrier to treatment.<\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.125.044794","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T11:06:59Z","timestamp":1773832019000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical, Functional, and Quality\u2010of\u2010Life Outcomes After Contemporary Transcatheter Edge\u2010to\u2010Edge Repair for Primary Mitral Regurgitation in the Very Elderly"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7892-2430","authenticated-orcid":false,"given":"Matthew J.","family":"Price","sequence":"first","affiliation":[{"name":"Scripps Clinic","place":["La Jolla, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9123-8038","authenticated-orcid":false,"given":"Gagan D.","family":"Singh","sequence":"additional","affiliation":[{"name":"University of California","place":["Sacramento, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3363-8070","authenticated-orcid":false,"given":"Jason H.","family":"Rogers","sequence":"additional","affiliation":[{"name":"University of California","place":["Sacramento, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"Atrium Health Sanger Heart and Vascular Institute","place":["Charlotte, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Mahoney","sequence":"additional","affiliation":[{"name":"Sentara Heart Hospital","place":["Norfolk, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3075-0203","authenticated-orcid":false,"given":"Paolo","family":"Denti","sequence":"additional","affiliation":[{"name":"San Raffaele Hospital","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4725-6217","authenticated-orcid":false,"given":"Wolfgang","family":"Rottbauer","sequence":"additional","affiliation":[{"name":"Ulm University Heart Center","place":["Ulm, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1744-5271","authenticated-orcid":false,"given":"Federico M.","family":"Asch","sequence":"additional","affiliation":[{"name":"Cardiovascular Core Laboratories, MedStar Health Research Institute, and Georgetown University","place":["Washington, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0487-1749","authenticated-orcid":false,"given":"Jose L.","family":"Zamorano","sequence":"additional","affiliation":[{"name":"Hospital Universitario Ram\u00f3n y Cajal","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4567-1411","authenticated-orcid":false,"given":"Janani","family":"Aiyer","sequence":"additional","affiliation":[{"name":"Abbott Structural Heart","place":["Santa Clara, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2801-1873","authenticated-orcid":false,"given":"Kelli","family":"Peterman","sequence":"additional","affiliation":[{"name":"Abbott Structural Heart","place":["Santa Clara, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3691-1709","authenticated-orcid":false,"given":"Francesco","family":"Maisano","sequence":"additional","affiliation":[{"name":"San Raffaele Hospital","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1356-0037","authenticated-orcid":false,"given":"Ralph Stephan","family":"von Bardeleben","sequence":"additional","affiliation":[{"name":"University Medical Center of the Johannes Gutenberg\u2010University Mainz","place":["Mainz, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelio","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Ascension Saint Thomas","place":["Nashville, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1547-4869","authenticated-orcid":false,"given":"Saibal","family":"Kar","sequence":"additional","affiliation":[{"name":"Los Robles Regional Medical Center","place":["Thousand Oaks, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.12.062"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2017-312605"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000932"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.09.015"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.11.041"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.26137"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2018.3359"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.01.010"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.09.029"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.05.014"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.7089"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.07.058"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2023.05.013"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.113.000354"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2024.01.033"}],"container-title":["Journal 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