{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:03:36Z","timestamp":1789715016532,"version":"4.0.1"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,4,7]]},"abstract":"\n Background<\/jats:title>\n \n Group 2 pulmonary hypertension (\n PH<\/jats:styled-content>\n ), defined as\n PH<\/jats:styled-content>\n caused due to left heart disease, remains a challenging condition. However, its prognostic impact and implications for emerging therapies are unclear. We aimed to evaluate the real\u2010world relationship between pulmonary vascular resistance (\n PVR<\/jats:styled-content>\n ) and prognosis in Group 2\n PH<\/jats:styled-content>\n and assess the efficacy of emerging therapies.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Two prospective registries supported by Japanese\n PH<\/jats:styled-content>\n societies were analyzed: a current (2018\u20132024; n=563) and a previous (2012\u20132016; n=425) registry. The composite end points were hospitalization for heart failure, all\u2010cause death, ventricular assist device implantation, or cardiac transplantation.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Stratified analyses using propensity score\u2013matched data demonstrated a significant association between\n PVR<\/jats:styled-content>\n >3 Wood units and prognosis in patients with Group 2\n PH<\/jats:styled-content>\n (6\u2010year event\u2010free rates,\n PVR<\/jats:styled-content>\n >\n 3<\/jats:styled-content>\n Wood units versus\n PVR<\/jats:styled-content>\n \u2266\n 3<\/jats:styled-content>\n Wood units, previous registry: 72.9% versus 61.4%; current registry: 75.2% versus 55.4%). Consistent patterns were observed in both heart failure with reduced ejection fraction and heart failure with preserved ejection fraction subgroups. The use of\n SGLT2<\/jats:styled-content>\n (sodium\u2010glucose cotransporter\u20102) inhibitors in the current registry was associated with improved outcomes in patients with elevated\n PVR<\/jats:styled-content>\n , showing event\u2010free rates of 73.8% versus 35.5% in those without treatment. Among multivariate analyses including major treatment options,\n SGLT2<\/jats:styled-content>\n inhibitor treatment exhibited significant associations with improvement of composite end points.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Elevated\n PVR<\/jats:styled-content>\n (>3 Wood units) identified a high\u2010risk subset of patients with Group 2\n PH<\/jats:styled-content>\n . The association between the use of\n SGLT2<\/jats:styled-content>\n inhibitors and better outcomes suggests a potential therapeutic role that warrants further investigation through controlled studies.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1161\/jaha.125.045155","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T09:46:44Z","timestamp":1774000004000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Impact of Elevated Pulmonary Vascular Resistance in Group 2 Pulmonary Hypertension: Insights From a Japanese Multicenter Registry"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1795-6872","authenticated-orcid":false,"given":"Taijyu","family":"Satoh","sequence":"first","affiliation":[{"name":"Tohoku University Graduate School of Medicine","place":["Sendai, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5354-9687","authenticated-orcid":false,"given":"Koichiro","family":"Sugimura","sequence":"additional","affiliation":[{"name":"International University of Health and Welfare Narita Hospital","place":["Narita, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8947-109X","authenticated-orcid":false,"given":"Yoshihiro","family":"Fukumoto","sequence":"additional","affiliation":[{"name":"Kurume University School of Medicine","place":["Kurume, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4131-5423","authenticated-orcid":false,"given":"Kohtaro","family":"Abe","sequence":"additional","affiliation":[{"name":"Kyushu University","place":["Fukuoka, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4240-2097","authenticated-orcid":false,"given":"Yoshihiro","family":"Dohi","sequence":"additional","affiliation":[{"name":"Kure Kyosai Hospital","place":["Hiroshima, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Dohi","sequence":"additional","affiliation":[{"name":"Mie University Graduate School of Medicine","place":["Tsu, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8430-2123","authenticated-orcid":false,"given":"Yu","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Kobe University Graduate School of Medicine","place":["Kobe, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9485-8635","authenticated-orcid":false,"given":"Akiyoshi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Sapporo Medical University School of Medicine","place":["Sapporo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3308-6392","authenticated-orcid":false,"given":"Shigehiko","family":"Kato","sequence":"additional","affiliation":[{"name":"Yamagata University School of Medicine","place":["Yamagata, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2313-017X","authenticated-orcid":false,"given":"Kazuto","family":"Nakamura","sequence":"additional","affiliation":[{"name":"University of Yamanashi","place":["Yamanshi, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Takama","sequence":"additional","affiliation":[{"name":"Gunma University Graduate School of Medicine","place":["Maebashi, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9607-0852","authenticated-orcid":false,"given":"Toru","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Kyushu University","place":["Fukuoka, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7108-7306","authenticated-orcid":false,"given":"Yusuke","family":"Yamada","sequence":"additional","affiliation":[{"name":"Tohoku University Graduate School of Medicine","place":["Sendai, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Terui","sequence":"additional","affiliation":[{"name":"Iwate Prefectural Isawa Hospital","place":["Sendai, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Miura","sequence":"additional","affiliation":[{"name":"Ishinomaki City Hospital","place":["Sendai, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8051-8982","authenticated-orcid":false,"given":"Masaki","family":"Ishiyama","sequence":"additional","affiliation":[{"name":"Mie University Graduate School of Medicine","place":["Tsu, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8165-5855","authenticated-orcid":false,"given":"Masayuki","family":"Koyama","sequence":"additional","affiliation":[{"name":"Sapporo Medical University School of Medicine","place":["Sapporo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9260-6901","authenticated-orcid":false,"given":"Fusako","family":"Sera","sequence":"additional","affiliation":[{"name":"The University of Osaka Graduate School of Medicine","place":["Osaka, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Tamura","sequence":"additional","affiliation":[{"name":"International University of Health and Welfare Mita Hospital","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5618-4721","authenticated-orcid":false,"given":"Yasushi","family":"Sakata","sequence":"additional","affiliation":[{"name":"The University of Osaka Graduate School of Medicine","place":["Osaka, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2135-3625","authenticated-orcid":false,"given":"Masaru","family":"Hatano","sequence":"additional","affiliation":[{"name":"The University of Tokyo","place":["Tokyo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Tohoku University Graduate School of Medicine","place":["Sendai, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Japan PH Registry Network Group 2 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