{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T05:21:18Z","timestamp":1787721678853,"version":"build-2784847793"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,7,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">To examine associations between accelerometer\u2010derived \u201cweekend warrior\u201d (WW) physical activity pattern (most moderate\u2010to\u2010vigorous\u2010intensity physical activity in 1\u20132\u2009days) versus moderate\u2010to\u2010vigorous\u2010intensity physical activity spread more evenly with risks of incident first cardiometabolic disease (FCMD)\u00a0and cardiometabolic multimorbidity (CMM) among hypertension participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">UK Biobank participants with hypertension (n=26891) provided a full\u2010week of accelerometer\u2010derived physical activity data between 2013 and 2015, processed using GGIR and a machine\u2010learning classifier. CMM was defined as the occurrence of at least 2 of type 2 diabetes, ischemic heart disease, and stroke. Three activity patterns (WW, regular, and inactive) were compared across multiple thresholds and definitions of active WW, with significance corrected for multiple comparisons at a false discovery rate of 0.05.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Over 7.5\u2009years median follow\u2010up, 2718 individuals developed FCMD and 219 developed CMM. Using the definition of WW as guideline\u2010based and \u226550% of total moderate\u2010to\u2010vigorous\u2010intensity physical activity over 1 to 2\u2009days via GGIR, we observed similarly lower risks of incident FCMD (WW versus inactive: hazard ratio [HR], 0.75 [95% CI, 0.69\u20130.82],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =1.4\u2009\u00d7\u200910\n                      <jats:sup>\u22123<\/jats:sup>\n                      ; regular versus inactive: HR, 0.85 [95% CI, 0.74\u20130.96],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =2.6\u2009\u00d7\u200910\n                      <jats:sup>\u22122<\/jats:sup>\n                      ) and CMM (WW versus inactive: HR, 0.59 [95% CI, 0.41\u20130.83],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =4.0\u2009\u00d7\u200910\n                      <jats:sup>\u22123<\/jats:sup>\n                      ). Both active WW and regular physical activity patterns were associated with lower risk of FCMD compared with inactivity, with no statistically significant differences between the 2 active patterns. However, the result of WW versus inactive for CMM showed no statistical significance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Increased activity, even when concentrated within 1 to 2\u2009days\/week may reduce cardiometabolic disease risk in individuals with hypertension.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.045185","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T10:22:34Z","timestamp":1783074154000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Associations of Accelerometer\u2010Derived \u201cWeekend Warrior\u201d Physical Activity Pattern With Incident First Cardiometabolic Disease and Cardiometabolic Multimorbidity in Individuals With Hypertension"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9308-7879","authenticated-orcid":false,"given":"Jia\u2010Qi","family":"Yang","sequence":"first","affiliation":[{"name":"Shengjing Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4082-1599","authenticated-orcid":false,"given":"Yu\u2010Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Shengjing Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1686-863X","authenticated-orcid":false,"given":"Qian\u2010Man","family":"Li","sequence":"additional","affiliation":[{"name":"Shengjing Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5475-3238","authenticated-orcid":false,"given":"Lu","family":"Liu","sequence":"additional","affiliation":[{"name":"Shengjing Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2176-2544","authenticated-orcid":false,"given":"Tian\u2010Jiao","family":"Wen","sequence":"additional","affiliation":[{"name":"Shengjing Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3813-8932","authenticated-orcid":false,"given":"Ting\u2010Ting","family":"Gong","sequence":"additional","affiliation":[{"name":"Shengjing Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9421-5114","authenticated-orcid":false,"given":"Qi\u2010Jun","family":"Wu","sequence":"additional","affiliation":[{"name":"Shengjing Hospital of China Medical University","place":["Shenyang, China"]},{"name":"China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2559-2754","authenticated-orcid":false,"given":"Shan\u2010Yan","family":"Gao","sequence":"additional","affiliation":[{"name":"Shengjing Hospital of China Medical University","place":["Shenyang, China"]},{"name":"Shengjing Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2024.155999"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.38361"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-022-01632-3"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41746-022-00676-9"},{"key":"e_1_3_2_6_2","volume-title":"Global Recommendations on Physical Activity for Health","author":"World Health Organization","year":"2010","unstructured":"World Health Organization . Global Recommendations on Physical Activity for Health. World Health Organization; 2010."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000000678"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.124.068669"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-025-02676-x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.2196\/46991"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001779"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169649"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1249\/mss.0000000000000289"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep45772"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehab250"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1249\/mss.0000000000000978"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2016.06.017"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.10875"},{"key":"e_1_3_2_19_2","unstructured":"National Health Service . Health Survey for England 2022 Part 1. Accessed February 24 2025. https:\/\/digital.nhs.uk\/data\u2010and\u2010information\/publications\/statistical\/health\u2010survey\u2010for\u2010england\/2022\u2010part\u20101."},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afaf370"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2021-104050"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.123.033610"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-022-02389-y"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-024-03819-9"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2022.2488"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41746-024-01135-3"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-024-00688-y"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00007.2025"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00386.2023"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2016.11.010"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2021.11.026"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.125.045185","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T04:39:43Z","timestamp":1787719183000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.125.045185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,7]]},"references-count":30,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2026,7,7]]}},"alternative-id":["10.1161\/JAHA.125.045185"],"URL":"https:\/\/doi.org\/10.1161\/jaha.125.045185","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,7]]},"assertion":[{"value":"2025-07-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e045185"}}