{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:03:46Z","timestamp":1789715026439,"version":"4.0.1"},"reference-count":63,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,4,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Placental abruption engenders powerful risks of maternal cardiovascular disease (CVD), but offspring risks are lacking. We examine the associations between abruption and the risks of all\u2010cause mortality and fatal and nonfatal CVD events in the offspring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We designed a retrospective cohort study using the PACER (Placental Abruption and Cardiovascular Event Risk) cohort (births in New Jersey, 1993\u20132020). We fit Cox proportional hazards models to estimate the abruption\u2010associated risks of mortality in singleton offspring and of fatal and nonfatal CVD events. These associations were replicated in a sibling\u2010pair analysis to minimize familial confounding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Of 2\u2009949\u2009992 singleton pregnancies, the abruption prevalence was 1% (n=28\u2009641). The median offspring follow\u2010up was 14.5\u2009years (range 0\u201328; 41.9\u2009million person\u2010years). The offspring CVD mortality rates among births with abruption and without abruption were 4 (n=17) and 1 (n=307) per 100\u2009000 person\u2010years, respectively (adjusted hazard ratio [HR], 4.64 [95% CI, 2.75\u20137.86]). The corresponding nonfatal CVD rates were 627 (n=2425) and 190 (n=79\u2009360) per 100\u2009000 person\u2010years, respectively (HR, 2.86 [95% CI, 2.74\u20132.98]). The risks were higher in analyses restricted to offspring aged &lt;1\u2009year with CVD events. These associations were similar in the sibling pair analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Offspring born of pregnancies complicated by abruption suffer an increased burden of mortality and CVD. CVD risks associated with abruption are evident during the infancy period and persist throughout the life course. These data underscore how microvascular placental dysfunction due to abruption can affect the offspring's CVD risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.045199","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T09:21:51Z","timestamp":1774430511000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiovascular Disease in Singleton Offspring Born of Pregnancies Complicated by Placental Abruption: A Population\u2010Based Retrospective Cohort Study"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0410-2595","authenticated-orcid":false,"given":"Cande V.","family":"Ananth","sequence":"first","affiliation":[{"name":"Rutgers Robert Wood Johnson Medical School","place":["New Brunswick"]},{"name":"Rutgers Robert Wood Johnson Medical School","place":["New Brunswick"]},{"name":"Rutgers Robert Wood Johnson Medical School","place":["New Brunswick"]},{"name":"Rutgers School of Public Health","place":["Piscataway"]},{"name":"Environmental and Occupational Health Sciences Institute, Rutgers Robert Wood Johnson Medical School","place":["Piscataway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1131-8148","authenticated-orcid":false,"given":"Emily B.","family":"Rosenfeld","sequence":"additional","affiliation":[{"name":"Rutgers Robert Wood Johnson Medical School","place":["New Brunswick"]},{"name":"Rutgers Robert Wood Johnson Medical School","place":["New Brunswick"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0592-3000","authenticated-orcid":false,"given":"Rachel","family":"Lee","sequence":"additional","affiliation":[{"name":"Rutgers Robert Wood Johnson Medical School","place":["New Brunswick"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Valeri","sequence":"additional","affiliation":[{"name":"Columbia University","place":["New York"]},{"name":"Harvard T.H. Chan School of Public Health","place":["Boston"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0543-9798","authenticated-orcid":false,"given":"William J.","family":"Kostis","sequence":"additional","affiliation":[{"name":"Rutgers Robert Wood Johnson Medical School","place":["New Brunswick"]},{"name":"Rutgers Robert Wood Johnson Medical School","place":["New Brunswick"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Cabrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zev","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001209"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyac210"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2023.05.006"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2023.11.009"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.154"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.191"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwab206"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.036748"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22887"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2022.06.059"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1599149"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.15420\/ecr.2021.18"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.054689"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.10.050"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-015-0085-7"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2014.03.001"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.05.021"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00134.2023"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l6398"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1017\/S2040174419000850"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2022-072157"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/2047487319852716"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.325.7356.157"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.13039"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.09.069"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.10.028"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr045"},{"key":"e_1_3_2_29_2","article-title":"Placental abruption, preterm delivery, and cardiovascular disease in twin offspring","author":"Lee R","year":"2025","unstructured":"Lee R, Rosenfeld EB, Valeri L, Kostis WJ, Ananth CV. Placental abruption, preterm delivery, and cardiovascular disease in twin offspring. J Am Heart Assoc. 2025. (In press)","journal-title":"J Am Heart Assoc"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/9780470316696"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000457"},{"key":"e_1_3_2_32_2","first-page":"1","article-title":"An R package for the analysis of completing risks and multi\u2010state models","volume":"38","author":"dW LC","year":"2011","unstructured":"dW LC, Fiocco M, Putter H; mstate . An R package for the analysis of completing risks and multi\u2010state models. J Stat Softw. 2011;38:1\u201330.","journal-title":"J Stat Softw"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/153.4.332"},{"key":"e_1_3_2_34_2","first-page":"195","article-title":"Neonatal intracranial lesions following placental abruption","volume":"153","author":"Gibbs JM","year":"1994","unstructured":"Gibbs JM, Weindling AM. Neonatal intracranial lesions following placental abruption. Eur J Pediatr. 1994;153:195\u2013197.","journal-title":"Eur J Pediatr"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(93)90138-K"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12553"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.14049"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-018-4974-3"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.123.21061"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvu013"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1992.tb13848.x"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1996.07030182.x"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(89)90710-1"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0708473"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008122"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003805"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneph0344"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0093-691x(99)00258-7"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.311.6998.171"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00440.2008"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1159\/000330666"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-001-0766-9"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.941203"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.06.046"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00191.2005"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.084889"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00641.2009"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00356.2011"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00005.2003"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1071-5576(03)00074-1"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-4917fje"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn341"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1515\/jpm.2010.126"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20110627"}],"container-title":["Journal of the American Heart Association"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ahajournals.org\/doi\/full\/10.1161\/JAHA.125.045199","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:36:36Z","timestamp":1789713396000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ahajournals.org\/doi\/10.1161\/JAHA.125.045199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,7]]},"references-count":63,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,4,7]]}},"alternative-id":["10.1161\/JAHA.125.045199"],"URL":"https:\/\/doi.org\/10.1161\/jaha.125.045199","relation":{},"ISSN":["2047-9980"],"issn-type":[{"value":"2047-9980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,7]]},"assertion":[{"value":"2025-07-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e045199"}}