{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:52:49Z","timestamp":1791355969915,"version":"4.3.1"},"reference-count":86,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"19","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,10,6]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Despite continuous advancements in devices and techniques, transcatheter aortic valve implantation remains associated with complications impacting outcomes. In 2021, the Valve Academic Research Consortium (VARC) introduced the VARC\u20103 criteria to better classify procedural complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We conducted a systematic review and meta\u2010analysis of studies reporting transcatheter aortic valve implantation\u2010related complications using VARC\u20103 definitions between 2021 and 2025. The primary end point was all\u2010cause mortality at latest follow\u2010up. Secondary end points included major VARC\u20103 complications and predictors of adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">A total of 57 studies with 73\u2009588 patients were included. The cohort had a mean age of 81.7\u2009years, 51.7% were women, and most had preserved ejection fraction (55.5%) and low\u2010to\u2010moderate surgical risk (Society of Thoracic Surgeons [STS] predicted risk of mortality [PROM] 4.1%). Technical and 30\u2010day device success rates were 95% and 90%, respectively; early safety rate at 30\u2009days was 66%. At average 12\u2009months follow\u2010up, all\u2010cause mortality was 10.2%. The most common complication was permanent pacemaker implantation (13%), followed by type 2 or greater bleeding (9.7%), acute kidney injury stage 3\u20134 (4.7%), major vascular events (4.3%), and stroke (3.0%). Moderate\/severe paravalvular regurgitation and patient\u2010prosthesis mismatch occurred in 4% and 8%, respectively. Study\u2010level pooled predictor analyses showed that acute kidney injury, type 2 or greater bleeding, paravalvular regurgitation, non\u2010structural valve dysfunction, and higher STS score were associated with higher mortality, while eccentric\/severe aortic valve calcification was associated with significant paravalvular regurgitation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Transcatheter aortic valve implantation shows high procedural success but non\u2010negligible complication rates under VARC\u20103 criteria. acute kidney injury, type 2 or greater bleeding, NSVD, periprocedural stroke and myocardial infarction after transcatheter aortic valve implantation were associated with higher mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.045455","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:13:27Z","timestamp":1790680407000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Incidence and Predictors of Complications After Transcatheter Aortic Valve Implantation According to VARC\u20103 Criteria: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1176-4300","authenticated-orcid":false,"given":"Federico","family":"Giacobbe","sequence":"first","affiliation":[{"name":"Citt\u00e0 della Salute e della Scienza","place":["Turin, Italy"]},{"name":"University of Turin","place":["Italy"]},{"name":"Royal Brompton and Harefield Hospitals Trust and Imperial College","place":["London, 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