{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T05:21:18Z","timestamp":1787721678275,"version":"build-2784847793"},"reference-count":57,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"13","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,7,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">This study aimed to investigate and validate the association of the discordance between apoB (apolipoprotein B) and low\u2010density lipoprotein cholesterol (LDL\u2010C) or non\u2013high\u2010density lipoprotein cholesterol with cognitive function and explore the mediating role of cerebral large\u2010 and small\u2010vessel diseases on this association, for which previous evidence was limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Community\u2010dwelling adults aged &gt;50\u2009years from the Polyvascular Evaluation for Cognitive Impairment and Vascular Events study were included in this cross\u2010sectional study. Global cognitive function was evaluated using the Montreal Cognitive Assessment. The association of the residuals between apoB and LDL\u2010C or non\u2013high\u2010density lipoprotein cholesterol levels with Montreal Cognitive Assessment score was explored using multivariate linear regression. The simple mediating effects of neuroimaging markers of cerebral large atherosclerotic disease and cerebral small\u2010vessel disease on this association were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">This study included 2916 participants (age: 61.01\u00b16.63\u2009years, female sex: 1553 [53.26%]). Total Montreal Cognitive Assessment scores and visuospatial\/executive function, naming, attention, language, abstraction, delayed memory, and orientation subscores differed significantly among 3 groups stratified by the residuals between apoB and LDL\u2010C. Increased residuals between apoB and LDL\u2010C were associated with decreased Montreal Cognitive Assessment score postadjustment. Intracranial atherosclerotic plaque presence and burden mediated 13.36% and 10.87% of this association, respectively; the mediation effect of intracranial atherosclerotic plaque presence postadjustment was 5.67%. The validation study confirmed these findings, with 10.04% and 9.08% postadjustment mediation effects of the presence and burden of intracranial atherosclerotic plaque, respectively, on the association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">High discordance between apoB and LDL\u2010C was associated with poor cognitive function, partially mediated by intracranial atherosclerotic plaque.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.045591","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T10:20:19Z","timestamp":1783074019000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Association of the Discordance Between Apolipoprotein B and Low\u2010Density Lipoprotein Cholesterol With 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