{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:55:13Z","timestamp":1787018113144,"version":"build-2736575974"},"reference-count":57,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,2,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Secondary mitral regurgitation is associated with adverse clinical outcomes and cardiac remodeling. While transcatheter edge\u2010to\u2010edge repair (TEER) improves symptoms and prognosis in selected patients, its effects on cardiac remodeling remain debated. This systematic review and meta\u2010analysis aimed to evaluate the impact of TEER on echocardiographic indices of cardiac remodeling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">PubMed, Scopus, and Cochrane Library were used to identify relevant studies assessing echocardiographic changes before and after TEER. Outcomes of interest were left ventricular (LV) ejection fraction, global longitudinal strain, LV end\u2010diastolic and end\u2010systolic volumes and LV end\u2010diastolic and end\u2010systolic diameter, tricuspid annular plane systolic excursion, pulmonary artery systolic pressure, and left atrial end\u2010systolic volume.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Forty\u2010two studies (3987 patients) were included. TEER was associated with a significant increase in LV ejection fraction (mean difference [MD], 1.51% [95% CI, 0.47\u20132.55]), without significant improvement in global longitudinal strain. Significant LV remodeling was observed, with reductions in LV end\u2010diastolic volume (standardized MD, \u22120.26 [95% CI, \u22120.37 to \u22120.14]), LV end\u2010systolic volume (standardized MD, \u22120.21 [95% CI, \u22120.30 to \u22120.12]), LV end\u2010diastolic diameter (MD, \u22122.35\u2009mm [95% CI, \u22123.66 to \u22121.04]) and left ventricular end\u2010systolic diameter (MD, \u22122.30\u2009mm [95% CI, \u22123.86 to \u22120.74). TEER also improved right ventricular function (tricuspid annular plane systolic excursion [MD, 1.29\u2009mm [95% CI, 0.60\u20131.97]) and reduced pulmonary artery systolic pressure (MD, \u22126.75\u2009mm\u2009Hg [95% CI, \u22128.53 to \u22124.97). No significant improvement in left atrial end\u2010systolic volume was detected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Available evidence suggests that TEER promotes significant cardiac remodeling in patients with secondary mitral regurgitation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.045616","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T11:01:15Z","timestamp":1770807675000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Echocardiographic Indices of Cardiac Remodeling Following Transcatheter Edge\u2010to\u2010Edge Repair for Secondary Mitral Regurgitation: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4045-2859","authenticated-orcid":false,"given":"Marco","family":"Lombardi","sequence":"first","affiliation":[{"name":"Universit\u00e0 di Genova","place":["Genoa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1010-2567","authenticated-orcid":false,"given":"Mattia","family":"Basile","sequence":"additional","affiliation":[{"name":"La Paz University Hospital","place":["Madrid, Spain"]},{"name":"La Paz University Hospital Research Institute (IdiPAZ)","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6362-7618","authenticated-orcid":false,"given":"Alfonso","family":"Jurado\u2010Rom\u00e1n","sequence":"additional","affiliation":[{"name":"La Paz University Hospital","place":["Madrid, Spain"]},{"name":"La Paz University Hospital Research Institute 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