{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:45:01Z","timestamp":1782992701097,"version":"3.54.5"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,3,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Acute vertebrobasilar artery occlusion is associated with mortality rates up to 80%. While endovascular thrombectomy has proven effective, patient selection remains challenging due to limited validated prediction models. This study aimed to develop and externally validate a nomogram for predicting 90\u2010day excellent functional outcome (modified Rankin Scale score, 0\u20131) in patients with acute vertebrobasilar artery occlusion undergoing endovascular thrombectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      A total of 819 patients with vertebrobasilar artery occlusion undergoing endovascular thrombectomy were enrolled in this study. Of these, 242 patients from 4 stroke centers were allocated to the training cohort, while 577 patients from the\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">PERSIST<\/jats:styled-content>\n                      (Posterior Circulation Ischemic Stroke) registry comprised the validation cohort. Multivariate logistic regression identified independent predictors for nomogram development. Model performance was assessed using the concordance index, calibration curves, and decision curve analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      The overall excellent outcome rate was 21.2%, with 85.1% achieving successful recanalization. Five independent predictors were identified: age &lt;65\u2009years (odds ratio [\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">OR],<\/jats:styled-content>\n                      0.96;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.006), baseline\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">National Institutes of Health Stroke Scale score<\/jats:styled-content>\n                      &lt;18 (\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">OR,<\/jats:styled-content>\n                      0.97;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.012), thrombectomy passes &lt;3 (\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">OR,<\/jats:styled-content>\n                      0.59;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.033), Basilar Artery on Computed Tomography Angiography score &gt;6 (\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">OR,<\/jats:styled-content>\n                      1.34;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.028), and successful recanalization (\n                      <jats:styled-content style=\"fixed-case\" toggle=\"no\">OR,<\/jats:styled-content>\n                      4.49;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.019). The nomogram demonstrated excellent discriminative performance, with a concordance index of 0.82 in the training cohort and 0.92 in external validation. Good calibration was confirmed (Hosmer\u2013Lemeshow test,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.514).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">We developed and externally validated a practical nomogram incorporating 5 clinical variables for predicting excellent outcomes in patients with acute vertebrobasilar artery occlusion undergoing endovascular thrombectomy. The model demonstrates robust performance and clinical utility, providing valuable support for evidence\u2010based decision making in posterior circulation stroke management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.045622","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T12:19:16Z","timestamp":1771589956000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Nomogram Model for Predicting 90\u2010Day Excellent Outcome in Patients With Acute Vertebrobasilar Artery Occlusion Undergoing Endovascular Thrombectomy"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7842-645X","authenticated-orcid":false,"given":"Song","family":"Pan","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Nanjing Medical University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue\u2010zhou","family":"Cao","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Nanjing Medical University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng\u2010hua","family":"Lv","sequence":"additional","affiliation":[{"name":"Northern Jiangsu People\u2019s Hospital","place":["Yangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Ding","sequence":"additional","affiliation":[{"name":"Taizhou People\u2019s Hospital","place":["Taizhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhensheng","family":"Liu","sequence":"additional","affiliation":[{"name":"The Affiliated Hospital of Yangzhou University","place":["Yangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Sun","sequence":"additional","affiliation":[{"name":"University of Science and Technology of China","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Jia","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Nanjing Medical University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin\u2010bo","family":"Zhao","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Nanjing Medical University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2010bin","family":"Shi","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Nanjing Medical University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4058-4413","authenticated-orcid":false,"given":"Sheng","family":"Liu","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Nanjing Medical University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2013.5007"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1084819"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-022-01008-5"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2207576"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30395-3"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.511162"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-5406-x"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000486690"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.018270"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.011598"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.831386"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.031371"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40560-020-00459-y"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/10760296221117991"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.7326\/M14-0697"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2020.106199"},{"key":"e_1_3_2_18_2","first-page":"274","article-title":"Stroke outcome prediction using admission NIHSS in anterior and posterior circulation stroke","volume":"33","author":"Kazi SA","year":"2021","unstructured":"Kazi SA, Siddiqui M, Majid S. 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