{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:39:55Z","timestamp":1792291195469,"version":"4.4.0"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,4,21]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">A novel computational angiographic microcirculatory resistance (AMR) derived from a single angiographic view presents a feasible alternative to the pressure wire\u2010based index of microcirculatory resistance. However, its prognostic significance in patients undergoing percutaneous coronary intervention (PCI) remains insufficiently established.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">This is a post hoc analysis of 3404 patients undergoing PCI from the FAVOR III China (Comparison of Quantitative Flow Ratio Guided and Angiography Guided Percutaneous Intervention in Patients With Coronary Artery Disease) trial. Pre\u2010 and post\u2010PCI AMR were measured in target vessels, with percentage change in AMR before and after PCI calculated as (100\u00d7[post\u2010PCI AMR\u2212pre\u2010PCI AMR]\/pre\u2010PCI AMR). The primary model used was the log\u2010rank test, and the proportional hazards model was also used to assess the association between AMR and the 3\u2010year risk of major adverse cardiac events, defined as a composite of all\u2010cause death, myocardial infarction, or ischemia\u2010driven revascularization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Patients with percentage change in AMR before and after PCI \u226585 (23.7%) versus &lt;85 (76.3%) had comparable baseline characteristics but received more and longer stents per patient. Overall major adverse cardiac events risk was similar between groups (14.8% versus 12.4%; hazard ratio [HR], 1.18 [0.95\u20131.45]; log\u2010rank\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.064). However, in patients with post\u2010PCI AMR \u2265250, percentage change in AMR before and after PCI \u226585 showed a significant increase in the major adverse cardiac events risk (16.3% versus 10.8%; HR, 1.52 [1.14\u20132.04]), contrasting with no difference when post\u2010PCI AMR &lt;250 (12.3% versus 13.4%; HR, 0.89 [0.63\u20131.25];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      <jats:sub>interaction<\/jats:sub>\n                      =0.019).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In patients undergoing PCI from the FAVOR III China population, significant AMR elevation (percentage change in AMR before and after PCI \u226585) in target vessels alone did not predict outcomes, but in the subgroup with post\u2010PCI AMR \u2265250 it identified patients at increased 3\u2010year cardiovascular risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>REGISTRATION<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">https:\/\/www.clinicaltrials.gov<\/jats:ext-link>\n                      ; Unique identifier: NCT03656848.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.045639","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T10:07:30Z","timestamp":1775556450000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic Value of Angiographic Microcirculatory Resistance After Coronary Intervention: Insights From the FAVOR III China Trial"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8493-4251","authenticated-orcid":false,"given":"Hongliang","family":"Zhang","sequence":"first","affiliation":[{"name":"Chinese Academy of Medical Science and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1800-4566","authenticated-orcid":false,"given":"Wence","family":"Shi","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Science and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Science and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guannan","family":"Niu","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Science and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengrong","family":"Liu","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Science and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changdong","family":"Guan","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Xie","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongqiang","family":"Zou","sequence":"additional","affiliation":[{"name":"Chinese Academy of Medical Sciences and Peking Union Medical College","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6287-3128","authenticated-orcid":false,"given":"Xiang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Huazhong University of Science and Technology","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4299-3752","authenticated-orcid":false,"given":"Ning","family":"Guo","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Xi\u2019an Jiaotong University","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8939-2922","authenticated-orcid":false,"given":"Fei","family":"Ye","sequence":"additional","affiliation":[{"name":"Nanjing Medical University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8538-6560","authenticated-orcid":false,"given":"Liansheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangsu Provincial People\u2019s Hospital","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2292-3725","authenticated-orcid":false,"given":"Jie","family":"Mi","sequence":"additional","affiliation":[{"name":"The First Hospital of Shijiazhuang","place":["Shijiazhuang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9681-1067","authenticated-orcid":false,"given":"Shengxian","family":"Tu","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbo","family":"Ge","sequence":"additional","affiliation":[{"name":"Shanghai Institute 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