{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:33:36Z","timestamp":1787236416475,"version":"build-2736575974"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,2,3]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Transcatheter aortic valve replacement using self\u2010expandable valves requires permanent pacemaker implantation (PPI) more often compared with balloon\u2010expandable systems. The Navitor prosthesis is a novel, tubular\u2010shaped self\u2010expandable valve with increasing use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">Thirty\u2010day PPI rates were compared between 148 patients treated with the Navitor system and 165 patients treated with the Evolut system. Patients with preexisting PPI, high\u2010risk ECG (right bundle\u2010branch block), and Navitor 35\u2010mm\/Evolut 34\u2010mm prostheses were excluded. Multivariable logistic regression was used to adjust for baseline differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Patients treated with Navitor were older (83.0 [IQR, 78\u201386] versus 81.0 [IQR, 76\u201384] years;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u20090.01) and had higher Society of Thoracic Surgeons mortality risk (5.6% [IQR, 3.0%\u20139.9%] versus 4.3% [IQR, 2.5%\u20137.0%];\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u20090.04). Overall, PPI occurred more frequently with Navitor (17.6%) than with Evolut (6.7%;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      \u2009&lt;\u20090.01), and this difference persisted after adjustment (adjusted odds ratio, 3.07 [95% CI, 1.10\u20138.40];\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      \u2009=\u20090.03; adjusted probability, 17.7% [95% CI, 15.1%\u201320.2%] versus 6.7% [95% CI, 5.5%\u20137.9%]). In patients with small annuli (&lt;430 mm\n                      <jats:sup>2<\/jats:sup>\n                      ), unadjusted PPI rate (9.1% versus 6.4%;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      \u2009=\u20090.55) and adjusted probabilities were similar (7.8% [95% CI, 5.0%\u201310.6%] versus 6.4% [95% CI, 4.8%\u20138.0%]; interaction\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      \u2009=\u20090.03). Within the Navitor cohort, PPI was more frequent with 27\/29\u2009mm than with 23\/25\u2009mm prostheses (22.3% versus 6.7%;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.02). Implantation depth was greater in Navitor patients requiring PPI (5.3\u00b11.8 versus 4.3\u00b12.2\u2009mm;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.04) and lower PPI rates (2.9% versus 30.8%;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.01) were observed with high target implantation depth.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Depending on prosthesis size, transcatheter aortic valve replacement with the Navitor system may have PPI rates comparable to other self\u2010expandable valves. High implantation of the Navitor may be attempted to reduce PPI rates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.045652","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T10:16:26Z","timestamp":1769768186000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Pacemaker Implantation Rates With the Self\u2010Expandable Navitor Valve"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8056-3908","authenticated-orcid":false,"given":"Michael","family":"Paukovitsch","sequence":"first","affiliation":[{"name":"Ulm University Heart Center","place":["Ulm, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Konjack","sequence":"additional","affiliation":[{"name":"Ulm University Heart Center","place":["Ulm, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0649-7364","authenticated-orcid":false,"given":"Dominik","family":"Felbel","sequence":"additional","affiliation":[{"name":"Ulm University Heart Center","place":["Ulm, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5753-7330","authenticated-orcid":false,"given":"Marvin","family":"Krohn\u2010Grimberghe","sequence":"additional","affiliation":[{"name":"Ulm University Heart Center","place":["Ulm, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonhard M.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Ulm University Heart Center","place":["Ulm, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"M\u00f6rike","sequence":"additional","affiliation":[{"name":"Ulm University Heart Center","place":["Ulm, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Rottbauer","sequence":"additional","affiliation":[{"name":"Ulm University Heart Center","place":["Ulm, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6190-2145","authenticated-orcid":false,"given":"Dominik","family":"Buckert","sequence":"additional","affiliation":[{"name":"Ulm University Heart Center","place":["Ulm, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","unstructured":"Fadahunsi OO Olowoyeye A Ukaigwe A Li Z Vora AN Vemulapalli S Elgin E Donato A. 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