{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T14:48:29Z","timestamp":1785509309514,"version":"3.56.0"},"reference-count":61,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,5,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Atrial fibrillation (AF) is the most common arrhythmia. Although it was recently identified as a risk factor for coronary heart disease (CHD), the underlying pathophysiology is not well understood. Biomarkers could provide insights on underlying mechanisms and identify potential predictors of CHD among people with AF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">The REGARDS (Reasons for Geographic and Racial Differences in Stroke) cohort study enrolled 30\u2009239 White and Black adults aged 45 and older in 2003 to 2007. Among those with baseline AF and no history of stroke or CHD, 13 cardiovascular risk biomarkers were measured at baseline. We calculated hazard ratios (HR) for incident CHD by biomarkers using Cox proportional hazards model adjusting for risk factors and use of statins, aspirin, and anticoagulants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Among 1818 participants with prevalent AF mean age was 69\u2009years (SD 10\u2009years). There were 201 (11%) cases of incident CHD over 9\u2009years. Several biomarkers were associated with incident CHD: NT\u2010proBNP (N\u2010terminal pro\u2010B\u2010type natriuretic peptide), GDF\u201015 (growth differentiation factor 15), C\u2010reactive protein, interleukin\u20106, D\u2010dimer, cholesterol, lipoprotein(a), triglycerides, low\u2010density lipoprotein, and gamma\u2010glutamyl transferase, with HRs 1.17 to 1.69 per SD increment. There were no associations for Factor VIII, galectin 3, and high\u2010density lipoprotein. The largest associations were for NT\u2010proBNP and GDF\u201015 with respective HRs per SD 1.69 (95% CI, 1.42\u20132.01) and 1.45 (95% CI, 1.21\u20131.74). Comparing the top versus bottom tertile, the largest associations were NT\u2010proBNP (HR 3.14 [95% CI 2.03\u20134.84]), interleukin\u20106 (HR, 2.69 [95% CI, 1.78\u20134.06]), and GDF\u201015 (HR, 2.20 [95% CI, 1.38\u20133.51]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Multiple biomarkers were associated with incident CHD in AF with the largest associations being myocardial strain and inflammation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.045735","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T10:00:20Z","timestamp":1776679220000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Blood Biomarkers and the Risk of Coronary Disease in Atrial Fibrillation"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3763-3971","authenticated-orcid":false,"given":"Andres","family":"Cordova Sanchez","sequence":"first","affiliation":[{"name":"University of Vermont Larner College of Medicine","place":["Burlington, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6190-735X","authenticated-orcid":false,"given":"Katherine","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"University of Vermont Larner College of Medicine","place":["Burlington, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3847-4768","authenticated-orcid":false,"given":"Samuel A. 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