{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:03:46Z","timestamp":1789715026304,"version":"4.0.1"},"reference-count":55,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,4,7]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Evidence has linked intracranial atherosclerotic stenosis (ICAS) with cognitive impairment in patients with stroke. We characterized ICAS associated with cognitive phenotypes in the general older population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">This study included 1031 participants without dementia from the community\u2010based MIND\u2010China (Multimodal Interventions to Delay Dementia and Disability in Rural China) magnetic resonance imaging substudy. The degree of stenosis was assessed using the Warfarin\u2013Aspirin Symptomatic Intracranial Disease criteria. ICAS was defined as arterial stenosis \u226550%. The ICAS burden was assessed according to the number and severity of ICAS. Mild cognitive impairment (MCI) was defined following Petersen's criteria. Amnestic MCI was defined as MCI with the presence of memory impairment. Data were analyzed using multivariable logistic and linear regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Of the 1031 participants, 240 (23.28%) had MCI. Higher ICAS burden was associated with increased likelihoods of MCI (odds ratio [OR], 1.89 [95% CI, 1.02\u20133.41]) and amnestic MCI (OR, 2.11 [95% CI, 1.13\u20133.92]), and reduced\n                      <jats:italic toggle=\"no\">Z<\/jats:italic>\n                      scores of global cognition (\u03b2, \u22120.21 [95% CI, \u22120.35 to \u22120.07]), memory (\u03b2, \u22120.40 [95% CI, \u22120.61 to \u22120.18]), and verbal fluency (\u03b2, \u22120.28 [95% CI, \u22120.47 to \u22120.08]). More severe ICAS was associated with lower memory\n                      <jats:italic toggle=\"no\">Z<\/jats:italic>\n                      score and a greater number of ICAS was associated with lower\n                      <jats:italic toggle=\"no\">Z<\/jats:italic>\n                      scores of global cognition, memory, and verbal fluency (all\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.05). Furthermore, the presence of ICAS in anterior cerebral, internal carotid, posterior cerebral, and basilar artery was associated with reduced\n                      <jats:italic toggle=\"no\">Z<\/jats:italic>\n                      scores of memory, verbal fluency, and attention (all\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">The severity and location of ICAS are crucial for the associations of ICAS with MCI, amnestic MCI, and poor cognition in older adults. Cognitive assessments are warranted for older adults with ICAS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.045747","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T10:08:25Z","timestamp":1774951705000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Characterizing Intracranial Atherosclerotic Stenosis Associated With Cognitive Phenotypes Among Older Adults Who Are Dementia Free: A Population\u2010Based Study"],"prefix":"10.1161","volume":"15","author":[{"given":"Xiaoyu","family":"Wang","sequence":"first","affiliation":[{"name":"Shandong Provincial Hospital affiliated to Shandong First Medical University","place":["Jinan, China"]},{"name":"Shandong Provincial Hospital Affiliated to Shandong First Medical University","place":["Jinan, 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