{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T13:54:13Z","timestamp":1781790853179,"version":"3.54.5"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,6,2]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The American Heart Association Predicting Risk of Cardiovascular Disease Events risk scores estimate cardiovascular disease (CVD) risk, including heart failure (HF) and atherosclerotic CVD (ASCVD) events. Whether they associate with subclinical CVD in an asymptomatic community population is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">We analyzed 1138 participants from the multicenter PBHS (Project Baseline Health Study) cohort, who underwent echocardiography and coronary artery calcium scoring and were free of known CVD. Subclinical CVD was defined as the presence of subclinical HF or subclinical coronary artery disease. Subclinical HF included left ventricular diastolic dysfunction, left ventricular hypertrophy, or low ejection fraction (&lt;50%). Subclinical coronary artery disease was defined as coronary artery calcium &gt;0. Predicting Risk of CVD Events 10\u2010year risk score associations with subclinical CVD were assessed using logistic regression and area under the receiver operating characteristic curve analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Median age was 52 (41\u201364) years; 64% were White; and 57% were women. Subclinical HF was found in 182 (16%) participants, predominantly with left ventricular diastolic dysfunction (14%). Diastolic dysfunction prevalence increased from 5.8% in low\u2010risk HF groups to 44.1% in intermediate\u2010\/high\u2010risk HF groups. Each unit increase in 10\u2010year HF risk corresponded to 2.67\u2010fold higher odds of diastolic dysfunction (95% CI, 2.25\u20133.18; area under the curve, 0.81). Subclinical coronary artery disease was present in 466 (41%) participants, with prevalence increasing from 28.5% in low\u2010risk ASCVD groups to 79.3% in intermediate\u2010\/high\u2010risk ASCVD groups. Each unit increase in 10\u2010year ASCVD risk was associated with 2.91\u2010fold higher odds of any coronary calcification (95% CI, 2.54\u20133.35; area under the curve, 0.80), increasing to 4.76\u2010fold for coronary artery calcium &gt;100 (95% CI, 3.70\u20136.12; area under the curve, 0.86) and 5.60\u2010fold for coronary artery calcium &gt;300 (95% CI, 3.89\u20138.05; area under the curve, 0.87).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">In an asymptomatic CVD\u2010free community sample, subclinical CVD was increasingly associated with higher 10\u2010year HF and ASCVD risks calculated by the Predicting Risk of CVD Events equations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.045753","type":"journal-article","created":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T04:30:53Z","timestamp":1780115453000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Association Between Predicting Risk of Cardiovascular Disease Events (PREVENT)\u00a0Risk Scores and Subclinical Cardiovascular Disease: Insights From the Project Baseline Health Study"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3343-1156","authenticated-orcid":false,"given":"Gracia","family":"Fahed","sequence":"first","affiliation":[{"name":"Stanford University School of Medicine","place":["Stanford"]},{"name":"Stanford University","place":["Stanford"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diona","family":"Gjermeni","sequence":"additional","affiliation":[{"name":"Stanford University School of 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