{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:03:39Z","timestamp":1789715019329,"version":"4.0.1"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,5,19]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Transcatheter aortic valve replacement (TAVR) has shown noninferiority to surgical aortic valve replacement (SAVR). However, patients with bicuspid aortic stenosis are often excluded from these studies. More insights between these procedures in this population is crucial for treatment selection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">In this multicenter observational study, patients with bicuspid aortic stenosis undergoing TAVR or SAVR were analyzed using propensity score matching. The primary outcome was a composite of all\u2010cause mortality, stroke, rehospitalization, or valve dysfunction at 1\u2009year.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      A total of 997 patients with bicuspid aortic stenosis underwent TAVR or SAVR. In the matched cohort of 256 pairs, the median age was 75.0\u2009years (interquartile range, 71.0\u201378.0), 234 (44.9%) were women, and the median EuroScore II was 1.83% (interquartile range, 1.34\u20132.86). One\u2010year cumulative incidence of the primary outcome was 15.0% in TAVR compared with 12.0% in SAVR (hazard ratio [HR], 1.35 [95% CI, 0.83\u20132.19],\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.23). Mortality (4.3% versus 5.0%,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.72) and rehospitalization (4.8% versus 6.4%,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.45) were similar between groups. Although rates of valve dysfunction (2.9% versus 0.5%,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.06) and stroke (5.3% versus 2.3%,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.10) were numerically lower in the surgical group at 1\u2009year, both the risk of stroke (subdistribution HR, 3.01,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.02) and valve dysfunction (subdistribution HR, 4.16,\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.03) were significantly higher in the TAVR group at 2\u2009years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">TAVR in patients with bicuspid aortic stenosis showed a similar 1\u2010year primary outcome rate compared with SAVR, though TAVR exhibited higher rates of valve dysfunction and stroke. These findings underscore the need for randomized trials to define the optimal treatment strategy for this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.045763","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T11:12:20Z","timestamp":1778757140000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Surgical Versus Transcatheter Aortic Valve Replacement in Bicuspid Aortic Stenosis: 1\u2010Year Clinical Outcomes in Patients Aged 65\u2009Years and Older"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7803-189X","authenticated-orcid":false,"given":"Kimberley Iris","family":"Hemelrijk","sequence":"first","affiliation":[{"name":"Instituto de Investigaci\u00f3n Sanitaria del Hospital Cl\u00ednico San Carlos (IdISSC)","place":["Madrid, Spain"]},{"name":"University of Amsterdam","place":["Amsterdam, The 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Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8873-4839","authenticated-orcid":false,"given":"Toon","family":"Winkelman","sequence":"additional","affiliation":[{"name":"University of Amsterdam","place":["Amsterdam, The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3357-5834","authenticated-orcid":false,"given":"Lluis","family":"Asmarats","sequence":"additional","affiliation":[{"name":"Hospital de la Santa creu i Sant Pau","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2258-3246","authenticated-orcid":false,"given":"Elena","family":"Rosello\u2010Diez","sequence":"additional","affiliation":[{"name":"Hospital de la Santa creu i Sant Pau","place":["Barcelona, 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