{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:26:50Z","timestamp":1792204010925,"version":"4.4.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,2,17]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">The Fontan operation results in chronic hemodynamic alterations, including central venous hypertension, which may contribute to gut dysbiosis. This study aimed to compare gut microbiota profiles between Fontan patients and age\u2010 and sex\u2010matched healthy controls and to examine how catheter\u2010measured hemodynamic and liver\u2010related parameters relate to microbial alterations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">This cross\u2010sectional study enrolled 23 Fontan patients and 23 matched controls. Fontan patients underwent cardiovascular assessments, and stool samples were collected from all participants. Gut microbiota profiles were analyzed using 16S rRNA gene sequencing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">Compared with controls, Fontan patients exhibited distinct gut dysbiosis, with lower evenness and significant shifts in beta\u2010diversity. Fontan patients had higher relative abundances of inflammation\u2010associated taxa and lower abundances of short\u2010chain fatty acid\u2013producing or commensal genera. Higher catheter\u2010measured pulmonary and Fontan\u2010circuit pressures and greater transpulmonary gradients were associated with lower microbial diversity and depletion of several beneficial taxa. In contrast, better liver status\u2014reflected by higher serum albumin\u2014coincided with more favorable microbial profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Fontan patients show a characteristic pattern of gut microbiota disruption that parallels their hemodynamic and hepatic burden. Treating Fontan\u2010related pressures as continuous variables revealed graded associations among circulatory congestion, liver involvement, and gut dysbiosis, supporting a hemodynamic\u2013gut\u2013liver axis in Fontan physiology. Specific bacteria may serve as potential microbial biomarkers for identifying patients at higher risk and for guiding therapeutic interventions aimed at improving clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.045962","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T11:01:47Z","timestamp":1770807707000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Association Between Hemodynamic Parameters and Gut Microbiota in Fontan Circulation: A Cross\u2010Sectional Study"],"prefix":"10.1161","volume":"15","author":[{"given":"Saviga","family":"Sethasathien","sequence":"first","affiliation":[{"name":"Chiang Mai University","place":["Chiang Mai, 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