{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:02:55Z","timestamp":1785250975393,"version":"3.55.0"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2026,5,5]]},"abstract":"<jats:sec xml:lang=\"en\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p xml:lang=\"en\">Mavacamten improves symptoms in obstructive hypertrophic cardiomyopathy, but real\u2010world prescription patterns, safety profile, and the effect of atrial fibrillation (AF) on outcomes remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p xml:lang=\"en\">An observational multicenter analysis using patient\u2010level data from the TriNetX database (2011\u20132023) compared patients with obstructive hypertrophic cardiomyopathy treated with mavacamten versus those not treated with mavacamten (controls). Multivariable logistic regression identified predictors of mavacamten use. Propensity\u2010score matching was used to reduce confounding bias. Outcomes included acute heart failure, left ventricular systolic dysfunction, cardiovascular hospitalization, new\u2010onset AF, and all\u2010cause mortality. Outcomes were also stratified by AF history.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p xml:lang=\"en\">\n                      Among 15\u2009145 patients, 509 (3.5%) received mavacamten; 502 matched to 1475 weighted 1:3 controls (equivalent to 502). Black patients were significantly less likely to receive mavacamten compared with White patients (odds ratio, 0.45 [95% CI, 0.33\u20130.63]). Of the 502 mavacamten recipients, 4.8% experienced acute heart failure, 8.3% experienced systolic dysfunction, 10.8% experienced cardiovascular hospitalization, 6.4% experienced new\u2010onset AF, and 1.4% died. Overall outcomes were similar between both groups except for a higher incidence of systolic dysfunction in mavacamten patients (log\u2010rank\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.001). Among mavacamten patients, those with baseline AF (28%) had significantly higher rates of acute heart failure (7.8% versus 3.6%;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.047), systolic dysfunction (12.8% versus 6.4%;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      =0.02), cardiovascular hospitalization (27.7% versus 4.2%;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.01), and mortality (5% versus 0%;\n                      <jats:italic toggle=\"no\">P<\/jats:italic>\n                      &lt;0.01). Older age independently predicted acute heart failure, whereas baseline AF predicted both cardiovascular and all\u2010cause hospitalization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec xml:lang=\"en\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p xml:lang=\"en\">Black patients have markedly lower access to mavacamten. Preexisting AF was associated with a higher risk of adverse outcomes for patients on mavacamten, highlighting the need for careful monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1161\/jaha.125.045994","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T09:14:58Z","timestamp":1777281298000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Mavacamten in Obstructive Hypertrophic Cardiomyopathy: National Insights on Access and Safety Profile From Real\u2010World Data"],"prefix":"10.1161","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0063-1692","authenticated-orcid":false,"given":"Ayman R.","family":"Fath","sequence":"first","affiliation":[{"name":"University of Texas Health Science Center","place":["San Antonio"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0902-3021","authenticated-orcid":false,"given":"Amro","family":"Aglan","sequence":"additional","affiliation":[{"name":"Westchester Medical Center, New York Medical College","place":["New York"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4073-5143","authenticated-orcid":false,"given":"Srihari S.","family":"Naidu","sequence":"additional","affiliation":[{"name":"Westchester Medical Center, New York Medical College","place":["New York"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0341-0641","authenticated-orcid":false,"given":"Michael J.","family":"Mader","sequence":"additional","affiliation":[{"name":"South Texas Veterans Health Care System","place":["San Antonio"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Chilton","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center","place":["San Antonio"]},{"name":"South Texas Veterans Health Care System","place":["San Antonio"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9853-7591","authenticated-orcid":false,"given":"Islam Y.","family":"Elgendy","sequence":"additional","affiliation":[{"name":"University of Kentucky","place":["Lexington"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9923-3853","authenticated-orcid":false,"given":"Martin S.","family":"Maron","sequence":"additional","affiliation":[{"name":"Lahey Hospital and Medical Center","place":["Burlington"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3953-0143","authenticated-orcid":false,"given":"Ethan J.","family":"Rowin","sequence":"additional","affiliation":[{"name":"Lahey Hospital and Medical Center","place":["Burlington"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.01.019"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.11.021"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001250"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.000849"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.076257"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.0252"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2022.04.048"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2023.3342"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.124.072445"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31792-X"},{"key":"e_1_3_1_12_2","volume-title":"CAMZYOS (Mavacamten) [Prescribing Information]","author":"Company B\u2010MS","year":"2025","unstructured":"Company B\u2010MS . 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