{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T15:23:43Z","timestamp":1766157823485,"version":"3.48.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"24","content-domain":{"domain":["www.ahajournals.org"],"crossmark-restriction":true},"short-container-title":["JAHA"],"published-print":{"date-parts":[[2025,12,16]]},"abstract":"<jats:p xml:lang=\"en\">Although CNP (C\u2010type natriuretic peptide) was first identified in brain tissue, its systemic expression and release is mainly located to the endothelial lining of the vasculature. As such, CNP should not be viewed as a classic blood\u2010borne hormone but rather as a local factor that supports the integrity of vascular function. Albeit CNP is structurally related to both ANP and BNP (A\u2010 and B\u2010type natriuretic peptide), the main signaling pathway is through a specific membrane\u2010bound receptor without crosstalk from endocrine ANP and BNP. CNP expression and CNP\u2010mediated effects can thus be uniquely targeted without interference from the related cardiac NPs. In this perspective, we present the CNP system as a largely overlooked target for potential intervention in cardiometabolic disease, hypertension, and diabetes before onset of complications and overt heart failure. To fully unleash this potential, with this perspective, we hope to fuel renewed interest with a focus on use of human in\u00a0vitro and ex\u00a0vivo systems as well as experimental medical approaches and human cohort data.<\/jats:p>","DOI":"10.1161\/jaha.125.046011","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T11:04:47Z","timestamp":1765451087000},"update-policy":"https:\/\/doi.org\/10.1161\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Perspectives on C\u2010Type Natriuretic Peptide in Cardiometabolic Disease"],"prefix":"10.1161","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6356-3829","authenticated-orcid":false,"given":"Jens P.","family":"Goetze","sequence":"first","affiliation":[{"name":"Copenhagen University Hospital\u2014Rigshospitalet","place":["Copenhagen, 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